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If there is a concern about selection criteria, might I suggest trying to coordinate one response, politely explaining why patients have concerns about Fukuda.

Thanks, that would seem to give more statistical significance. We’ll have to await the data though.

In essence, the more things you test for then the higher the likelihood you'll find something that is just the result of random chance. Thus, when calculating a p-value (defined as, if there was no relationship, what is the chance that this result could occur?) we must adjust it for the number...

I've thought for a while that the delay in PEM (for me, 24-36 hours generally) is closest in experience for a healthy person to an extreme form of delayed onset muscle soreness (DOMS). Any of you that used to run regularly will have experienced the fact that the pain from pushing oneself is...

I think one of the (many, many) problems I have with the 'does radiation cause ME/CFS?' question is, firstly, what type of radiation is being proposed as a causative agent here? In what part of the spectrum? Gamma radiation? X-rays? UV? Ionising? Non-ionising? 'Radiation' as a term sounds...

Is that 70 patients after having selected IDO2 as the gene of interest though? If one is testing other genes as well in that population of 70 then one needs to do a correction for multiple comparisons.

I'll want to see the paper to see the definition of 'reacted' here. Especially given the high placebo response in the Rituximab trial.

Good to see a replication study even (especially?) when it doesn't replicate. The ME/CFS field is littered with contradictory, unreplicated findings and we need studies like this to trim the various results down to those that can be shown to be rigorous. As for the Myhill group, I have always...

Abstract aside, it's not a particularly bad paper. Doesn't add anything new but does provide a reasonable commentary on some recent results.

It's a good article. One thing that struck me was how much the TED talk look has influenced all modern day speaking, and how much it looks like something you'd see in tele-evangelism. Here is a problem that makes people in the audience unhappy; here is a simple solution presented by a...

I believe we had a good thread on this in the past, I'll see if I can dig it out (though working until gone 8pm tonight *sob*). I'll roughly repeat what I think I wrote in that one: this is an area that is fraught with controversy as to what illness people with recovery stories actually had...

Which would tie in with this study (summary here)- one that I'd really like to see follow-up and/or replication of.

See my other recent post that fantastic claims (be they about radiation poisoning, vaccines, 'chemicals' or now biological warfare experiments) need fantastic evidence. Personally, Occam's razor applies. Which is more likely? That the above is true? Or that psychiatrists - in the vein of...

Oh God, I’ve dug into the hypothesis a bit more and have fallen down the biophoton rabbit hole. Send help.

Thing is, if you’re going to propose radiation, vaccines, or unspecified ‘chemicals’ then you’d better have some damn good data to back it up, otherwise you’re not going to exactly dispel the myth that we’re all delusional.

I treat vaccine claims with a massive amount of scepticism and believe that, given the significant potential and actual harm that can come from making unfounded claims about vaccines, any such claims had better be watertight. I don’t think the above study meets such a requirement.

This would be a bigger concern if there had been a statistically significant difference between the groups but some overlap in results. As it is, there was no overlap in results so it cannot be an artefact of control/patient matching. That suggests it’s either: 1) a genuine result, with a...

Agree 100%. Indeed, I'd go further and say if this disease was one day to be shown by faulty brain wiring or whatever I wouldn't necessarily have a problem with that: but even if that were to be true it would remain the case that CBT and GET are ineffective, as are denial of medical tests and...

TBF, they also say "Although all of the above are possible contributing mechanisms, further experiments are required to understand the precise contributing mechanisms behind the observed differences, and whether they are specific to ME/CFS or whether the response might be found among other...

IMHO: Don't tweet this at anyone. If it turns out to have less specificity than hoped (and it hasn't been tested on any other non-ME/CFS condition) then it'll look bad. And if it turns out to be "the" biomarker then the BPS paradigm will continue to unravel anyway. Just remember, one...