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Patents can take many years to be granted but the information in them can be published after filing. I think after a year the patent application is published (but that could have changed).

The Pdf document says that Will Marsh is the author and he is head of media. So it looks like something from the universities PR department.

I would really like to know who in Bristol University issued the statement and who authorized it. It seems to me that Bristol university are saying there is nothing wrong with the ethical approvals (or lack of ethical approval in one case) for Crawley and Sterne's work. Lets not forget Crawley...

I wonder what the psychologists in the audience made of that. (or would have made of it if she had a patient label rather than an academic label).

That is basically PACE with CBT/GET as well as Smile. Crawley's trials are designed to use this effect to get a positive effect. I think there is also a timing issue in when forms are filled out. If you give people the chance to send forms back over a month or two they may wait till they are...

I think some of the idea behind the longitudinal studies where they follow families and their health for decades gives a better picture because its not retrospective and biased by looking for bad events when people are ill. But it is very hard to get over the huge number of potential factors...

I thought the angle of looking at digital tools was great as it suggests ways that employers can be inclusive and do things to help people work and collaborate.

The Cochrane response to Robert Courtney's comments are very telling. They basically say they will ignore the outcome switching in the PACE trial and rate it highly anyway and also give unconvincing excuses for their own outcome switching.

This was a talk that he gave a while ago on mitrocondria and ME

The UK biobank have shared samples with Karl Morten at Oxford University to look for metabolites & other chemical clues. http://cureme.lshtm.ac.uk/biobank-samples-received-dr-karl-morten/

I think it means they don't have sufficient people in the trial to show their expected effect size reliably so they talk about multi-arm stuff where they basically say because CBT and GET are similar we can agregate results.

Whenever I see the phrase Evidence-based treatment associated with ME it tends to be being used to promote CBT and GET which have really weak evidence because the trials are so bad. Good treatments that really work don't seem to need to push such labels.

I think it is a bad idea. I can see it could cause serious relapses.

I think there was a German team looking at antibodies who were doing a trial with some sort of blood filtering to try to remove anti-bodies. It should work more quickly than Rituximab but for a much shorter time. I think there was talk about doing that along with Rituximab so that any antibodies...

It doesn't quite work like that in the UK. I had a doctor who said Vitamin D wasn't important as its low in half the population. GPs don't like to test and don't really know what to do when its bad.

Yes had a similar experience. I think there is some research in terms of MS that suggests that vitamin D (or the lack of it) effects the strength of the blood brain barrier. I'm not sure we should take a paper looking for associations between the CFQ and anything seriously. Its too poor a...

Kate E Earl, Giorgos K Sakellariou, Melanie Sinclair, Manuel Fenech, Fiona Croden, Daniel J Owens, Jonathan Tang, Alastair Miller, Clare Lawton, Louise Dye, Graeme L Close, William D Fraser, Anne McArdle, Michael B J Beadsworth Abstract Objective Severe vitamin D deficiency is a recognised...

I think it is interesting that they do because it makes a clean cohort where the issues won't be suspected to come from other causes.

From the bits of the paper I read they were careful to to over claim. We can talk about correlation and causation and here I think it is important to understand the findings in the context of what we know about cell biology and hence what the statistics mean in terms of the mechanisms we...

From the press release So it looks like a before and after exertion study which I think is exactly what we need in terms of ME and understanding the dynamics of the illness. It maybe that tests require this rather than a static snapshot.