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There are websites setting out the process but they are confusing, From https://www.myresearchproject.org.uk/help/hlpamendments.aspx#1 The boundaries don't seem clear around converting a feasibility study to a full study. This link also seems relevant...

I don't think I am write and I think they are trying to mislead. The letter I quoted suggesting they had ethical approval for the change: http://www.bristol.ac.uk/media-library/sites/ccah/documents/Ethics%20-%20Amendment%202%20-%2020%20August%202012%20-%20Reply.pdf Is from the hospitals R&D...

This is one I've never come across before. My first thought was it doesn't make sense for chronic illness. I guess the paper you pointed to sounds like it didn't find anything of interest but I've only scanned the abstract. I can see that people who have had and recovered from acute illnesses...

I'm assuming this is an independent replication of the two day exercise testing.

Amendment 2.0 seems to have been reviewed by the R&D committee which I assume is the full thing? It includes So it looks like the ethics committee did approve the conversion to a full study. But I still think that seems dodgy. In that I would question whether they gave it their full attention...

From this letter http://www.bristol.ac.uk/media-library/sites/ccah/documents/Ethics%20-%20REC%20Review%20of%20SMILE%20Project%20Letter.pdf I thought that he was promoting the fact the trial was being done by the NHS.

I notice that they have not included information about the two amendments just the letters saying they were accepted. The two lines refer to the same document which appears to be a convenient mistake. So as far as I can tell by scanning through the documents they have not said what the...

I tend to think that here we are not really a market for academic papers. They are too expensive. But we have an interest in the research and reading it. The real issue for the journals if they loose the personal subscriptions and library subscriptions that bring in the big money. I can...

I wouldn't be surprised if she got angry letters from parents of her patients (I was tempted but didn't - I did tell a social worker as a passing comment that I thought she represented a danger to children by pushing GET and activity based therapy). But given the child protection issues are...

She is not actually a psychiatrist her first papers were on things like leukemia, IL-10 in RA/Lupus. Which I think means she should know better and should understand her methodology is poor. But I like the idea of someone giving a presentation as an edgy beat poem. Or perhaps as a more modern...

I thought there was evidence around certain anti-depressants being good for chronic pain. But I guess this is looking at just depression. I thought there were some suggestions that anti-depressants may work better for pain than depression. Something to do with slowing/blocking signals in the brain.

I couldn't find the CDI questions but it does seem to be tested on a small group Wiki says: https://en.wikipedia.org/wiki/Children's_Depression_Inventory The comment on diabetic children suggests that as a scale it is not robust to co-morbid conditions. Given the issues with questionnaires...

In my world there are malware analysts who ask lots of unconventional questions and quite a few seem to have strange backgrounds and not necessarily degrees etc. Security is another thing where there is a mentality to do it well.

I think critical thinking and doing well at school can be very different. I do think there is a mentality for a researcher which is to question everything and want to understand. But people who do well at school and university don't need that mentality - it can even hold people back.

I've done that

That doesn't surprise me. I think the processes are set up for certain types of samples. I seem to remember reading the gene expression work needed very fresh samples. I'm also concerned about the whole freezing process given the latest Newton paper which shows frozen and fresh samples...

I think since then there has been metabolics work done which is interesting and may be very important. But I feel we are still at the stage of research providing potential clues which need following up with bigger research projects rather than anything definitive.

Did that lead to a high dropout rate? If it does it makes the ITT figures difficult.

There are gaming laptops http://www.bestadvisers.uk/best-gaming-laptops?s=go The HP Omen one is the best buy in that review. Or I have an HP Z-book which is their mobile workstation product (as a laptop its quite heavy but the new ones look quite thin and light). But they are not as powerful...

I'm not sure what you want in terms of integration Our twitter account is https://twitter.com/s4me_info Tweets pasted into messages should show in the message.