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I think Sharpe might actually agree with this:

For anyone else who needs the beginner's guide to clonal expansion, there is a clear, simple, explanation in this video from the Khan Academy (about 10 mins). Basically, first of all lots of unique T cells are produced in the thymus, and travel to the lymph nodes. When a pathogen comes along...

The latest update from OMF, about 9 minutes long. Summary: Their interest is T lymphocytes, which are prime movers of the immune system and come in several different flavours. They have been studying them for 35 years. Have seen evidence of major T cell activity in the blood of ME/CFS...

Full paper, http://sci-hub.tw/10.1007/s12529-018-9732-1

Well they won't be able to say they didn't know. That's two MPs and the senior medical advisor to the government whom Dave T has made aware of the issues, and the risk to children. I think @dave30th is earning his money!

This is a review article. I'm posting it for background reference, and because the description of FND signs in the paper doesn't look anything like ME (not to say that there isn't overlap, but this set of signs doesn't capture or describe ME. It sounds distinct and rather different)...

Sharpe's logic skewered again by @JohnTheJack:

In short, the simulation suggests that auditing a small percentage of papers would improve quality, but it would be expensive. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195613

For sure. He's still absolutely wedded to the conviction that it was a good trial, and it's just a few people being partisan and emotional that is the problem: He knows, he just dismisses the majority of the academics as unqualified to judge, and biased - full (start) of thread for context, not...

Yes, I think this is the case. Ironically, I think he is as convinced of his position as we are of ours, and doing exactly what we are - trying to make the other side see reason. This is where an appeal to the evidence ought to resolve things, of course, but for that to work everyone has to...

Since fecal transplants came up at IiME13 this week, this seemed topical. The article, https://mobile.nytimes.com/2018/06/02/health/fecal-transplants-bacteria-antibiotics.html The paper, https://www.nejm.org/doi/full/10.1056/NEJMc1803103

My assumption would be that they didn't want to presuppose anything about PEM, or at least no more than was unavoidable. This seems to be borne out by a section discussing limitations of the study:

Surely you can't conclude that the thought was any more than peripherally relevant, in the way that eg, having legs is relevant for the test to occur, without testing to see whether a similar group that have the thought but are then told after all not to do the exercise have the same CPET...

heresy /ˈhɛrɪsi / belief or opinion or (esp.) scientific evidence contrary to orthodox BPS doctrine; opinion profoundly at odds with what is (mistakenly) accepted: the heresy of being uncommitted to the right psychosocial dogma. Origin: Middle English : from Old French heresie, based on...

I read that as, both physical and cognitive exertion and emotional distress caused PEM for 90% of people in the study. It then goes on to say, "Almost all were affected by exertion but 14 (10%) reported no effect with emotion", and "Exertion precipitated significantly more symptoms than...

Yes, although I was assuming sudden onset cases argue against that as far as initial cause goes, but I guess the CPET studies are not done until some time into a person's illness, so not discriminatory. I hope it is something like this, because presumably there is then the possibility of...

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197811

This can only be true if ME is an umbrella term for several different illnesses, or if it is the etiology of one sub-group. Considering PWME who were athletes/sportspeople/regular joggers before becoming ill, presumably their pre-illness capabilities preclude the possibility of unhelpful...