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  1. Jonathan Edwards

    Open letter to Action for ME with concerns about their promotion of a problematic Care and Support Plan Template

    In theory, yes, but if you work in an organisation that rightly considers it is obliged to have trustees with relevant skills relating to professional aspects and always has to have some trustees to fulfil its obligations you may be a bit stuck. You would need to have trustees happy to admit...
  2. Jonathan Edwards

    Fatigue and psychiatric disorder: Different or the same? 1999 Chalder, Wessely

    Some of his efforts have quite clear meanings, I think. which is why people disagree with him! It is the level of meaninglessness that struck me here. Sort of distilled meaninglessness - single malt.
  3. Jonathan Edwards

    Open letter to Action for ME with concerns about their promotion of a problematic Care and Support Plan Template

    I can understand the problem for Sonya and maybe for the charity as a whole, whoever that actually consists of. There really aren't many people to turn to. when it comes to people actually involved in ME/CFS service provision there is hardly anyone that seems to be up to speed on NICE 2021. In...
  4. Jonathan Edwards

    Cytoplasmic stress granules: a cause of cellular dysfunction in ME/CFS?

    Well that seems to prove it. Anything trendy and irrelevant will have masses of review articles!! If a biological concept that gets a name like this it means it is being worked on by people who do not really understand how to do biology. Maybe someone has found some heaps of RNA, which might...
  5. Jonathan Edwards

    Fatigue and psychiatric disorder: Different or the same? 1999 Chalder, Wessely

    Bizarre that Wessely should put his name to something quite as meaningless as this.
  6. Jonathan Edwards

    Cytoplasmic stress granules: a cause of cellular dysfunction in ME/CFS?

    There is always talk of heat shock proteins when people don't know. And oxidative stress. And granules. And every time it is a totally new way of looking at whatever it was we were looking at. I suspect the granules taste of star anise. All except the orange ones, that is.
  7. Jonathan Edwards

    United Kingdom: Brakespear Clinic - Dr Basant Puri; Dr Joan Monro

    That is a debatable point but I also think things are more complicated. People like Monro have also had a global impact in terms of generating all sorts of fairy stories about things like allergies and much of the BPS can't is directed at people's 'false beliefs' in such stories. The two groups...
  8. Jonathan Edwards

    United Kingdom: Brakespear Clinic - Dr Basant Puri; Dr Joan Monro

    To my mind two wrongs don't make a right. I had to pick up the pieces after Dr Monro failed to provide appropriate treatment for people with progressive destructive arthritis over the years. moreover, they came to me because they had bankrupted themselves paying for quack treatments. And if we...
  9. Jonathan Edwards

    Fibrin drives thromboinflammation and neuropathology in COVID-19, 2024, Jae Kyu Ryu et al

    Some of them had died in bed, or in a subway, and so they did not have much respiratory symptoms. If that is the level of argument I am not impressed, especially as one of the key features of Covid was severe hypoxia without much respiratory symptoms. The stuff from the a paper all seems very...
  10. Jonathan Edwards

    Open letter to Action for ME with concerns about their promotion of a problematic Care and Support Plan Template

    All credit to Sonya for a clearly argued and rapid response. I can understand why this would have been difficult to pre-empt on her part.
  11. Jonathan Edwards

    Hoarse raspy voice- how and why?

    I think if speech problems are linked to ME/CFS their origins will be as unknown as everything else in ME/CFS. There won't be any helpful medical facts! The priority has to be to exclude some other cause. Whether or not speech therapy would be helpful for problems associated with ME/CFS I...
  12. Jonathan Edwards

    The Suggested Relationships Between Common GI Symptoms and Joint Hypermobility, POTS, and MCAS 2024 Quigley et al

    Just to add, it pains me to see such a high proportion of my physician colleagues swallowing all this stuff about hypermobility. (They are less receptive to MCAS.) The first ten years of my research programme focused specifically on connective tissue biology and I used to write the medical...
  13. Jonathan Edwards

    The Suggested Relationships Between Common GI Symptoms and Joint Hypermobility, POTS, and MCAS 2024 Quigley et al

    Yes but the same gastroenterologists who are finding themselves having to give this support for 'functional' (i.e. imaginary) problems associated with the putative real structural or biochemical (MCAS) problems they have invented are also rewriting review articles saying it is time they stopped...
  14. Jonathan Edwards

    Fibrin drives thromboinflammation and neuropathology in COVID-19, 2024, Jae Kyu Ryu et al

    I find it hard to link these experiments to any significant understanding of human clinical problems. Injecting fibrinogen into brain is bound to activate microglia and has no relevance to either acute neurological events in humans or LC as far as I can see. It may be interesting that fibrinogen...
  15. Jonathan Edwards

    How to write a good introduction for an ME/CFS paper?

    I think @Ravn 's basic idea is not to say anything much. Say the paper is about ME/CFS, just as you would say it is about MS or cancer, and assume the reader knows what you are talking about. Data papers are there to report observations relating to testing hypotheses. Reviews are there to tell...
  16. Jonathan Edwards

    The Suggested Relationships Between Common GI Symptoms and Joint Hypermobility, POTS, and MCAS 2024 Quigley et al

    Maybe physicians need to ask themselves whether it is them that are making people ill by inventing all these non-existent diseases. These are the same people who are denying people with ME/CFS life saving nutritional support on the grounds of their illness being 'functional'.
  17. Jonathan Edwards

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    I know very little about this sort of biochemistry but choline seems to crop up everywhere.
  18. Jonathan Edwards

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    Fascinating. What more can I say! The lipid shifts may be more than just confounding co-morbidities too, but I think these oddball findings like SOD3 and BCHE are easier places to start.
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