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  1. Estherbot

    Book Review: CBT: The Cognitive Behavioural Tsunami

    At the end of the article, there is a link to a talk given by the author Dr. Farhad Dalal in 2015 (it's not given a hyperlink on the Mad in America site). It's 46 minutes long. Disclaimer: I've not watched it!
  2. Estherbot

    Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?(2019) - G.Morris,Maes,Berk,Puri

    Like most of you I have struggled with terminology & language used. However I did find this via Self Hacked (admittedly not always the most reliable source, however you may find the explanations on leaky gut, endotoxins, LPS etc a useful starting point.)...
  3. Estherbot

    Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?(2019) - G.Morris,Maes,Berk,Puri

    Interesting list of authors... Anybody know more about Gerwyn Morris or Michael Maes? On some of the quoted papers Morris is listed as a resident of Llanelli....(@JohnTheJack a near neighbour to you)
  4. Estherbot

    A unifying theory for cognitive abnormalities in functional neurological disorders, Fibromyalgia and CFS (2018), Mark J Edwards et al.

    Also selection criteria for ME/CFS are not discussed anywhere nor the magic phrase PEM. As a side note, I'veI've across quite a few people in my area are diagnosed as having ME/CFS but with psychological trigger such as a nervous breakdown rather than a viral or infectious one. This paper...
  5. Estherbot

    A unifying theory for cognitive abnormalities in functional neurological disorders, Fibromyalgia and CFS (2018), Mark J Edwards et al.

    The limitations section after the Discussion is worth noting. Throughout the paper "heterogeneous" crops up a lot. :) Limitations Evidence for the presence and characteristics of cognitive abnormalities in FNDs, FM and CFS is remarkably heterogeneous. Sample sizes were usually small, and a...
  6. Estherbot

    Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome (2018)

    Full paper is available via Sci Hub https://sci-hub.tw/10.2217/epi-2017-0150
  7. Estherbot

    The “scandal” of the PACE trial for CFS/ME, BLB Solicitors

    *I understand that Sharpe (& Wessely) have set up Google alerts relating to their work, which is maybe why they are quick to respond on subjects like PACE and the colourful language they have used about patients in the past. *PS Narcissistic personality disorder on Wikipedia
  8. Estherbot

    The “scandal” of the PACE trial for CFS/ME, BLB Solicitors

    Wonder if Michael Sharpe will threaten the solicitors with libel?
  9. Estherbot

    Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS (2018) Newton et al

    PS Mark Guthridge is definitely worth following on Twitter. He seems a knowledgeable communicative guy.
  10. Estherbot

    Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS (2018) Newton et al

  11. Estherbot

    Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS (2018) Newton et al

    Dr Mark Guthridge of Monash University in Melbourne has given his thoughts on the possible use and results of giving Metformin to ME/CFS patients on Twitter. They chime with reports on various forums given by Valentijn & others.
  12. Estherbot

    Michael Sharpe skewered by @JohntheJack on Twitter

    Prof Michael Sharpe's Oxford home & choice of venue for "special ethics" lectures.
  13. Estherbot

    Michael Sharpe skewered by @JohntheJack on Twitter

    Enter James Coyne stage left
  14. Estherbot

    Michael Sharpe skewered by @JohntheJack on Twitter

    Michael Sharpe latest
  15. Estherbot

    Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS (2018) Newton et al

    Like @Trish, I've been trying to understand AMPK signalling without causing instant brain fog. Found this video on YouTube, which has enlightened me slightly. Out of many things AMPK does, it instructs cells to take in more glucose to make more ATP and to store less glucose as glycogen (in the...
  16. Estherbot

    Michael Sharpe skewered by @JohntheJack on Twitter

    My favourite from MS's output today.... Nasty allegation. Your analysis is invalid. Sorry
  17. Estherbot

    Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS (2018) Newton et al

    From the discussion "The important findings from this study are that, firstly, pharmacological activation of AMPK can improve glucose uptake in skeletal muscle cell cultures from patients with ME/CFS and secondly, cellular ATP content is significantly reduced in ME/CFS muscle cell cultures...
  18. Estherbot

    Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS (2018) Newton et al

    How the study was funded "Acknowledgements The work was funded by ME Research UK and supported by the NIHR Newcastle Clinical Research Facility."
  19. Estherbot

    Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS (2018) Newton et al

    There's always a race to say this. ;)
  20. Estherbot

    Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS (2018) Newton et al

    There's also a thread from AndyPandy who talks about their experiences withMetformin as a type 2 diabetic. They may be very different from people without Type 2 diabetes. ME and Metformin http://forums.phoenixrising.me/index.php?threads/me-and-metformin.47425/
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