Search results

When looking at the criteria there are the symptoms that must be included or a certain number. But the other thing work consideration is the exclusion criteria in terms of co-morbidities. One factor that I think Oxford talks about is that fatigue needs to be the primary symptom so if people...

A shame they needed to but yes.

I thought this was an interesting twitter response.

There was also a collegue of Chris Pointing (from Edinburgh) at the CMRC conference who was interested in B cells and starting to think about ME.

Its 2mb at the moment

Some are saying that the excess death rate is a more accurate way to look at the figures given recording problems. Deaths are recored as Covid-19 deaths if the person tested positive so no tests no record - which could have a big effect on reported numbers. I wonder what type of varience would...

This was an article I saw https://www.vox.com/2020/7/12/21321653/getting-covid-19-twice-reinfection-antibody-herd-immunity

I did see one article where there seem to be a small number of well documented cases of reinfection. I think they were talking about 3 months but where someone was tested positive with symptoms, got better tested twice with negative results and back to normal then got symptoms again and positive...

The only interesting thing from such trials would be to compare the different response biases that they measure with different diseases.

It can be years!

I can see the psych lobby trying to grab this money for badly run cbt and get studies.

Support for the motion here https://www.sinnfein.ie/contents/57170 From Chris MacManus MEP @Tom Kindlon I don't know if you keep a list of Irish MPs/MEPs who make sympathetic statements on ME if you do here is one.

If you are asking the same question in multiple ways (i.e. multiple outcomes essentially measuring the same thing) then you should worry if they don't provide the same answer (high correlation between measures). If they don't then you have an issue with something in your experiment which needs...

What methods are they using to deal with uncertainty from a mathematical perspective? [Adding additional comments] The methods are of course critical in that any underlying assumptions of (since uncertaintly is mentioned) known distributions, normal data or error, or linearity of measures and...

If a trial is designed with bad primary outcomes then then that should lead to basic questions being asked about the competence of those running the trial. If they can't select sufficiently good primary outcomes then are the capable of running other aspect of the trial.? Hence I would say if a...

yes

Yes I was also arguing that other measures from such a trial may be valid. I also like the idea of looking for correlations between multiple measures if they are essentially trying to measure the same thing then all the measures should correlate. In some instances there may be errors but if the...

I was careful in stating the intersection of Oxford and the other criteria as well as this is what they measured and yes they did strange things with the criteria. But I don't believe they selected a set of patients which their favored interventions would work with my intuition looking at the...

The way I would think about it is there are all these different ways that people interact each with different chances of spreading the virus and where different amounts of the population take part. The spread will then be a function of the numbers of infected people doing each of the activities...

I'm not sure why pain outcomes are valid for an unblinded surgery trial. An important question is how you would judge reliability which I can only see being done by correlating with other non-subjective measures (or less subjective measures). I suspect there is also an effect size issue - where...