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The question is not about self reports but about biases that are introduced due to self reports and whether they are mitigated by having a properly controlled trial. In the case of something like PACE where the intervention is designed to change how people think about an illness then the...

I think there is a basic question around whether data quality should exclude trials. This can take multiple forms such as the measures are too subject to biases (such as subjective outcomes with an open label trial) they could be because the measurement systems are simply not reliable etc...

Within each trial where data is included how much investigation is done into the trial and exactly what was measured. For example if they were to use the 6min walking test for PACE would they do enough work to find that the way it was administered was wrong as they didn't have a long enough...

One of the things with school attendance is it doesn't represent performance or how well a student is doing. So they may be their physically but not concentrating vs more limited attendance where they are doing more learning. There can also be places in schools for children who aren't well to...

One of my issues is around whether any protocol could be sufficient to look at the current trials. I certainly think that any protocol that uses subjective outcomes as its end-points is not worth bothering with. This could be made worst if (as with the current protocol) they use the CFQ as a...

This paper is the one that talks about the immune response being there in uneffected people - I think because they are saying that there is some recognition of the spike proteins in some people from other infections. That is a different issue as to whether antibodies formed for SARS-CoV2 will...

I noticed this tweet from an MP (Concerning the government removing on-line voting and making MPs queue to vote) who suffers from POTS and thought it was worth flagging as she may be sympathetic

The thing with asymptomatic cases is probably more complex in that there may be people with mild symptoms who basically just ignore them and carry on as normal. They're not really asymptomatic but behave as if they were. I think as a society we have become quite conditioned to trying to carry on...

One of the things I have seen suggested is the need to provide support for people who are isolating. Currently I suspect many people would find it hard to stay at home and not go out for 14 days as they don't have that much food in the house and can't get delivery slots. I don't know if this...

@sTeamTraen has raised some stats issues with this paper

I think this may be an interesting set of tweets around the spread pattern into the US with references to a couple of paper. The point I think is that the outbreak in Washington state had two particular mutations and there seems to be a lack of evidence for versions recorded in Wuhan or even...

It does surprise me how little data there seems to be about things like where spread seems to be happening. It suggests that they are either not trying to analyse spread patterns or don't want to talk about it. To me this data should help with any form of tracing. Hospitals and care homes seem...

That also suggests that any reported infection figures are very sensitive to sampling strategies (as well as the accuracy of tests). I was thinking that they may be over counting because it would be harder to reach those who are doing the most to self isolate. But without a paper setting out the...

This is an interesting article as to Mongolia who acted early and have had no cases of transmission (although they have imported cases). They basically acted in January to prepare.

Why not add that as a comment on the current review as I assume they still need to comment on these whilst a new process is in place. I don't think it is a point they have commented on before and it would be interesting to see what they say when confronted with a comment that one of the...

There is slightly more here https://www.royalholloway.ac.uk/media/13333/lss-scholarhsip-phd.pdf

This is something I've wondered about. I think one of the things with microfluidic devices is that they can use very small amounts of a sample e.g. small droplets so that could have a difference. Also there could be something around the accuracy of impedance measurements - I don't know about...

I thought this was quite an interesting article around the evidence about whether it is safe to reopen schools. Unlike a lot of press coverage it does talk about the limited but various pieces of research looking at children mentioning population studies including children such as one in Vo...

@sTeamTraen has published an interesting blog about some of the failures of a modelling paper https://steamtraen.blogspot.com/2020/05/the-perils-of-improvising-with-linear.html With reference to the paper Stedman, M., Davies, M., Lunt, M., Verma, A., Anderson, S. G., & Heald, A. H. (in press)...

It is about the spread dynamics. How people live and therefore the way they contact others will be a key component in how spread happens. If there are common households with people who are expected to go out and act normally and people who are vulnerable then this clearly is an issue and a...