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The service is RUH Bath (i.e. the hospital trust) not the university. Crawley works for Bristol University. In general I'm not impressed with the letter. I think if someone didn't understand the issues then they wouldn't get much from reading this. I also object to the ME isn't CFS as there is...

They claim that in trials GET does no harm but most trials didn't bother to look. PACE was relatively good in that it did look but I think they changed there definition of serious deterioration in the Lancet paper from the full protocol. It was hard to meet because the deterioration needed to be...

I think these stories are far too common. My father new someone who was told he had stress headaches but it was too late when it turned out to be a brain tumor. Doctors are encouraged to dismiss patients these days as the worried well. I don't know what the motivations have been in the past...

I suspect they did two different analyses one with men and women and a different one looking for correlations with income so they may not have explored the relationship. Then the journalist combines these in a single sentence. It would be interesting to know what else they looked at (say age...

(Sorry a long complex question) I have a question around collecting, testing and interpreting samples. ME becomes worse with exertion and this can last multiple days. Should we therefore consider the body as a dynamic system when taking samples and thus always take them with an understanding...

I think you should name them so that parents are warned. Last time QMUL or Barts (basically White) wrote a submission to NICE saying aids and adaptations should not be given to patients.

I think if anyone has paid they should ask for a refund because the CFQ (not scale) is not fit for purpose in measuring fatigue and it certainly isn't a scale.

Its a case of methodology and understanding the algorithms. When training a classifier on data you can give very good results on training data with low error it doesn't mean that the classifier will generalize at all to any unseen data or it that it hasn't picked up on irrelevant features in the...

But when generating a formula like this based on the data you need separate training and test sets otherwise the regression will just pick up on random variations within the given test set based - that is what the regression optimization is designed to do. The way that you know if it works is to...

I know that at least one 3d printer manufacturer is printing parts of its printers. But I don't think they deliver half a printer and expect you to print the rest out yourself. But they are working on printing metal, electronics etc so perhaps one day!

Machine learning techniques would certainly find patterns in data that humans wouldn't but care needs to be taken that they are not superficial features of the data or collection devices. But the big issue is availability of large volumes of data. Here there is work on things like nano sensors...

I think that shows the danger of things like MUS.

I was a bit confused about this because you seem to have 5 responders and 5 non responders. I assume you did a regression calculation to generate a hyperplane that separates the two groups and this gives the equation you quote and hence the ROC curve. However, its normal to use different data...

They come from the revolutionary communist party I believe.

There isn't really any evidence to point to in these areas. Without a good understanding of mechanisms its just clustering of reported symptoms and people making guesses over what is important/different.

Its fair to consider them in the guideline scope which I assume says they can look for evidence and give advice on that. I suspect they will find very little evidence but if they do look at what causes deterioration they they may find some evidence for too much activity (or anecdotal evidence...

I think @Graham is somewhere near the area

I'm clearly missing out on some history here.

Just to point out that this is an Edwards who worked at Liverpool hospital and seems to only have published 2 papers. Not Jonathan Edwards.

I assume she didn't understand why they are meaningless.