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It did make me wonder. Quite a lot of people with ME seem to have an intolerance to drugs and I believe some antidepressants are particularly bad. So it did make me wonder if drug intolerance could be a valid subgroup but then people would have had to have tried the drugs to know they were...

I only just realized that this comes from 2009. I think status of the arguments have moved on in terms of a better understanding of the failures in the evidence for CBT. I was going to say it sounds like he had a dodgy briefing but I wondered if the claims for CBT as a cure were pushed more...

I have a theory that when someone is starting to feel a little better they look for potential treatments, try things like this and continue to improve. When it is nothing to do with what is being tried and the improvement started prior to testing the treatment. Which is of course why we need...

Its an exploratory subgroup analysis so they may have looked for lots of possible subgroups and could have just come on one at random where there is a difference.

I agree and if you need high numbers in a trial chances are the effect is small.

The way stats testing works is that you try to reject the null hypothesis (that two groups are the same) and in doing do try to show a difference between the groups. In doing this the sample size makes a difference. This is why in doing a trial a power calculation is normally done to workout the...

Yes and I don't see why they can't quote both. Sometimes differences between the mean and median are informative in terms of the distribution but it would be better if they gave scatter plots. I thought this was becoming common. That lets the reader see the distribution of the data.

Thats the one. They are developing a new service not analyzing service data http://www.virology.ws/2017/08/28/trial-by-error-no-ethical-review-of-crawley-school-absence-study/

I would generally favor the median as it is more robust to outliers and makes less assumptions about linearity of any scale.

Is this the one that Tuller wrote about as it didn't have ethical approval?

I meant the argument that if a couple of individuals send angry messages that constitutes a campaign of harassment from the ME community. I probably hadn't read your message carefully.

Whilst she would use such an argument I don't think it is valid. I would see it as a form of discrimination in that the actions of individuals are being used to discredit a whole group.

Sometimes if people have competing theories and different directions it makes sense to keep them separate. Trying to force groups together can cause conflict. If there are two different bets at Stanford that seems like a good idea. However it is a shame they don't share samples and other equipment

I've no idea what is in his mind. But the thing that seems really important is the way the review mechanism is set up and who is pulled onto the committee. This is what needs to be analysed/commented on and influenced. Then there is the evidence that gets looked at. My feeling is that there is...

I think we may register as a charity in which case we could probably register as a stakeholder. Do organizations need an 'official status' Do you know if there is any definition of a group?

I think that is why Baker's comments of the formation of the committee are particularly important. Sounds like he knows the guidelines are bad and they will remain bad if the committee is the same as before. Given their previous chair's 'training videos' pushing GET and her husband then I...

Also a lot of the rules apply to drug trials only so trials of other interventions such as CBT are not as heavily regulated.

There were minutes from the MRC published somewhere (I think as an appendix in a welfare report) where Sile Lane and MRC representatives signed up to saying that FoI and parliamentary questions were harassment. I assume she will give the same message to the select committee that if they ask...

Universities may be trying to run like companies but they are very different (at least from US companies). One big think is around lines of management which are clear in companies with people being judged by profit. Its common for senior managers in companies to get sacked/move on when they...

I don't think people with ME have a very loud voice in that is it hard to be heard in the media. Although there have been a limited number of good stories over the last few years, If, however, as Crawley asserts that people with ME don't have a voice the answer is not to speak for them without...