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  1. Andy

    Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort... 2022 Parker et al

    Full title: Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome Background Post Exertional Symptom Exacerbation (PESE) is a characteristic symptom of Post-COVID Syndrome (PCS)...
  2. Andy

    Assessing Functional Capacity in [ME/CFS]: A Patient Informed Questionnaire [FUNCAP], 2024, Sommerfelt et al

    I have limited context, and I'm also aware of how challenging it can be to create a good questionnaire, however my thought on all of these questions, and probably some of the others as well, is that it's not clear whether the person answering should factor in the potential travel to the...
  3. Andy

    People don’t mate randomly – but the flawed assumption that they do is an essential part of [genome wide association studies], Border & Zaitlen, 2022

    Well, I'm not the expert on these things but I would assume that is one of the reasons why we are using the data from the UK Biobank as our control group, thereby controlling for geography as much as is possible.
  4. Andy

    The utility of wearable devices in assessing ambulatory impairments of people with multiple sclerosis in free-living conditions 2022 Sun et al

    Highlights • Disability level (assessed by six-minute walk test) in people with multiple sclerosis was estimated using the data collected from wearable devices in free-living conditions. • Fitbit minute-level step counts were analysed from which features were extracted. • Elastic net, gradient...
  5. Andy

    Toward a possible trauma subtype of functional neurological disorder: Impact on symptom severity and physical health 2022 Paredes-Echeverri, Perez

    Background As a group, individuals with functional neurological disorder (FND) report an approximately 3-fold increase in adverse life experiences (ALEs) compared to healthy controls. In patients with FND, studies have identified a positive correlation between symptom severity and the magnitude...
  6. Andy

    Psychological consequences of long COVID: comparing trajectories of depressive and anxiety symptoms... 2022 Fancourt et al

    Full title: Psychological consequences of long COVID: comparing trajectories of depressive and anxiety symptoms before and after contracting SARS-CoV-2 between matched long- and short-COVID groups Abstract Background There is a growing global awareness of the psychological consequences of long...
  7. Andy

    Severe myalgic encephalomyelitis/chronic fatigue syndrome in children and young people: a British Paediatric Surveillance Unit study 2022 Crawley et a

    "Case definition CYP with severe ME/CFS were defined using a three-stage procedure. First, paediatricians used a surveillance case definition to identify CYP (box 1). The study team then applied the exclusion criteria. Cases were then reviewed by the expert ME/CFS panel, which consisted of...
  8. Andy

    UK: The Big Give Christmas Challenge, 29th Nov - 6th Dec 2022

    ME Research UK. "Absolutley amazing! Unbelievable! We realised it was a 'big ask' for the 'Big Give' but you have, our wonderful supporters, topped our fundraising target of £7000 which will be match funded by our Pledgers. Not only that but the total amount raised (including matched funds) is...
  9. Andy

    Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis 2022 Taylor et al

    Abstract Background Intestinal inflammation disrupts the microbiota composition leading to an expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in microbiota composition is a profound change in the metabolic landscape of the intestine. It is unclear how...
  10. Andy

    Crosstalk between glucose metabolism, lactate production and immune response modulation 2022 Ye et al

    Abstract Metabolites of glycolytic metabolism have been identified as signaling molecules and regulators of gene expression, in addition to their basic function as major energy and biosynthetic source. Immune cells reprogram metabolic pathways to cater to energy and biosynthesis demands upon...
  11. Andy

    Reduced Muscle Strength in Patients with Long-COVID-19 Syndrome Is Mediated by Limb Muscle Mass 2022 Ramírez-Vélez et al

    Abstract Understanding the impact of COVID-19 on muscle strength may help to elucidate the organ systems that contribute to acute and chronic COVID-19 sequelae. We questioned whether patients with postdischarge symptoms after COVID-19 had compromised muscle strength compared with a control...
  12. Andy

    STIMULATE-ICP-Delphi ... : Study protocol 2022 van der Feltz-Cornelis et al

    Full title: STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol Abstract Introduction As mortality rates from COVID-19 disease fall, the high prevalence of long-term...
  13. Andy

    Reliability and validity of the post COVID-19 condition stigma questionnaire: A prospective cohort study 2022 Damant et al

    Summary Background Many of the 10–20% percent of COVID-19 survivors who develop Post COVID-19 Condition (PCC, or Long COVID) describe experiences suggestive of stigmatization, a known social determinant of health. Our objective was to develop an instrument, the Post COVID-19 Condition Stigma...
  14. Andy

    International: Science for ME social media posts

    Reddit post of November's News in Brief posts. https://www.reddit.com/r/cfs/comments/z9jm1n/the_mecfs_and_related_news_in_brief_posts_for/
  15. Andy

    Closed UK: DecodeME updates, was recruitment thread.

    "We are live again! You can now register https://bit.ly/3VAvjla to take part in...
  16. Andy

    Predictive model for long COVID in children 3 months after a SARS-CoV-2 PCR test 2022 Nugawela, Crawley et al

    Abstract Background To update and internally validate a model to predict children and young people (CYP) most likely to experience long COVID (i.e. at least one impairing symptom) 3 months after SARS-CoV-2 PCR testing and to determine whether the impact of predictors differed by SARS-CoV-2...
  17. Andy

    Closed UK: DecodeME updates, was recruitment thread.

    We are currently experiencing technical problems with the #DecodeME questionnaire portal. It is being investigated and we will let you know once it is resolved; in the meantime, apologies to anybody inconvenienced by this.
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