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Highlights • Fatigue is the main sequela of long COVID-19 and needs follow-up. • There are physical and mental manifestations of fatigue in long COVID-19. • This review presents the most used instruments in assessing fatigue in long COVID-19. • Muscle strength, walking, and functional tests...

Full title: Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination. Abstract Background Emerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in...

"Philippa Langley, whose search for the remains of Richard III forms the centre of new movie The Lost King, says she was keen to be honest with the writers about her life with ME. Myalgic encephalomyelitis, also known as chronic fatigue syndrome, is a long-term condition which can cause extreme...

Thought this would be useful to post here. With spit kits being sent out to donors some have been asking if a sample being delayed in the post would be an issue. The simple answer is that the likely delay caused by a postal strike is very unlikely to cause any issue. The storage tube contains...

Highlights • COX7A isoforms drive structurally distinct respiratory chains: C-MRC and S-MRC • C-MRC and S-MRC display different bioenergetic properties • C-MRC is favored when the PDH complex is activated, promoting OXPHOS • Metabolic shift toward glycolysis stabilizes SCAFI and the S-MRC...

Full title: Prevalence of medically unexplained symptoms in adults who are high users of healthcare services and magnitude of associated costs: a systematic review Abstract Introduction Medically unexplained symptoms (MUS) is a common clinical syndrome in primary and secondary healthcare...

Abstract We previously hypothesised that Functional Cognitive Disorder is characterised by heightened subjective mental effort, exhausted attentional reserve and metacognitive failure. To test this hypothesis, we administered a colour-word Stroop task in which attentional demand was varied by...

Comparison of these latest figures with the previous figures.

Well, both the Twitter and Facebook posts linked in my post above have a video demonstration of what to do. Also this small selection of feedback on social media seems to suggest that we haven't done too badly in making the instructions as clear as possible. "Received and returned my DecodeME...

Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 6 October 2022 1.Main points An estimated 2.3 million people living in private households in the UK (3.5% of the population) were experiencing self-reported long COVID (symptoms continuing for more than four...

$6,917 raised, 25 days left. https://crowdfund.berkeley.edu/project/33528

"Long Covid is affecting 2 million patients in the UK, and GPs are struggling to treat them. But the volume of patients may prompt more research into treatment for medically unexplained symptoms. Emma Wilkinson reports While the world remained in lockdown in the early waves of the pandemic and...

For those asked to donate a sample, spit kits are now being sent out. "#DecodeME participants also asked for a DNA sample will receive a spit kit in the post soon. It may take some time for the many kits to be sent out. Don’t worry as they are on their way. If you have received yours...

But your answers to the questionnaire still count. Thank you for taking part.

Full title: Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms Abstract Coronavirus disease 2019 (COVID-19), represents an enormous new threat to our healthcare system and particularly to...

Highlights Female predominates in childhood-onset psychogenic nonepileptic seizures (PNES). Early life trauma, specifically sexual abuse, was common in girls with PNES. Learning disability was a significant contributing factor in boys with PNES. Girls were more likely to experience suicidal...

Abstract Long-lasting coronavirus disease 2019 (COVID-19) symptoms beyond 12 weeks, the so-called ‘long COVID’ have been increasingly reported worldwide. Long COVID can be manifested in various forms, and there is an increasing demand for proper assessment and management. However, it is...

Post-COVID-Syndrome consists of several pathobiologically different entities, ranging from damage to specific organs to new onset autoimmune diseases. This article focuses on post-COVID courses with the leading symptoms of fatigue and exercise intolerance. This category is also known from other...

$5,755 raised, 26 days left. https://crowdfund.berkeley.edu/project/33528

My personal experience, which is four or five procedures with sedation in the last five years, is that as far as I can tell I had no adverse effects.