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Yeah, tuberculosis destroys lung tissue and one reference I saw said that 50% of patients had permanent pulmonary dysfunction. So, not breathing well due to lung damage, maybe coupled with years of smoking and old age - it's going to look pretty much like a vaguely defined chronic fatigue...

My apologies for the hypocrisy, with me having just posted - as I've just put on my moderator hat in response to reports ... This topic of 'patients behaving badly, or not, and the impact of such behaviour' is off-topic for the thread. It has also been thoroughly discussed on this thread...

The problem is that the bar for things being considered 'asshole-y by others' can be very low. For many people, just politely disagreeing with them is unacceptable, or politely pointing out the flaws in their arguments. Submitting FOIs has been seen as egregiously asshole-y by some. Of course...

For the benefit of those outside NZ, we have the Accident Compensation Corporation that pays compensation to anyone who has an accident. The idea was to stop a situation with costly litigation resulting in unfair outcomes. So, the government is responsible for the compensation, and industries...

Just further on that, in case anyone wanted to respond to Essen University: from the BMJ: Mental disorders are highly prevalent in Germany They found that "the 12 month prevalence for any mental disorder was 31%" in this random sample of German adults. PTSD was not assessed. So, it's actually...

Or logic. It gets very hard to use the prevalence of psych diagnoses as suggesting something about the 100% when you realise that probably 20% of the entire adult population of Germany have a prior psych diagnosis these days. e.g. for depression alone

Ha, perhaps not have a medical advisor who promotes the idea that there is an ME/CFS personality or that singing in the shower is a useful treatment? Perhaps not promote courses for people with ME/CFS that have them examine their personality for flaws that can be fixed? Perhaps not embark on...

Thank you Samuel. I'd love to think that campaigning to have our human rights recognised would bear fruit. The ongoing stream of terrible papers suggesting it is our personalities and lack of will that are at fault do seem to amount to hate speech, and have similar negative impacts as hate...

For what it's worth - I looked at my old lab tests. There are 9 measures of my total CO2/bicarbonate, a measure of CO2 in the blood. They all have been within normal range, tending to the high side. The one time it was below normal range, my CRP was abnormally high, even for me, so perhaps...

And it continues. Cancer patients continue to die, convinced that what they really need to do to get better is to reform their personality. I know of one person in my extended family, a mother of 5 boys, who eschewed biological therapies for her cancer in favour of therapy to fix the flaws in...

Yes. And I'm saying that that is a problem. They found some people had low end tidal Co2 levels when lying down, before doing the lean test. Yes, it's possible that the whole getting to the clinic and just being there is stressful, but why the variability between visits, with levels being low...

There are various versions, generally involving a mask and some with 'nasal prongs' which sound anxiety inducing but are, I think soft plastic that goes just inside the nostrils. The fact that some people didn't have low end tidal CO2 on their first two visits, but did have on their third...

A number of posts have been moved to Funding of ME/CFS research in the UK

Yeah, just thinking this over, it's hard to feel as though anyone involved in this study is approaching the problem of ME/CFS with any sense of urgency. See this, from the paper: So, it's not like it is some early exploratory work. (I checked a couple of times to make sure that I had the...

Another thing that struck me about the results was the inconsistency. Abnormalities of any sort were only found in 60% of the patients. But, of course, that does not necessarily mean that patients aren't experiencing the abnormalities when they have PEM. Three of the 29 patents who came in...

(Apologies, I'm thinking aloud here, in writing. Just trying to understand. I think there have been a number of studies related to hypocapnia in ME/CFS but I'm not sure what we should make of them yet.) So the measurement was CO2 in the breath. Hypocapnia is actually low CO2 in the blood...

There's some 2019 posts about Natelson and Hypocapnia here March 11th CDC Conference Call Also the Systrom paper is relevant Unexplained exertional intolerance associated with impaired systemic oxygen extraction - 2019, by Melamed, Systrom et al

Just in case you were wondering what the scales in the two charts mean, here's the detail from the paper. Note, for the Objective Activity, that the chart has a truncated y axis - the oldest trick in the book to make non-significant differences look more different. Only baseline levels of...

Yes, that is quite a result. So, the 'fast responders' thought they were doing increasing amounts of activity after treatment, but actually they were doing pretty much the same amount of activity throughout. Which is why we need actimeters to be used in these sorts of trials.

There's a thread for it here: Physiological assessment of orthostatic intolerance in chronic fatigue syndrome, 2022, Natelson et al