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That's great @cassava7. I don't think I realised that the current published Cochrane exercise review was only based on 3 studies. @Medfeb, for your information. I suppose BPS proponents might claim that there are more studies now, although of course the flaws in the studies themselves are a...

That's great, @Joan Crawford, thank you.

(this is not all word for word, but pretty much what Dr Systrom said) "We never ever simply prescribe exercise as a fix. What we do do, and we have had luck with this, and [there's some evidence] is that exercise is judiciously combined with medications. We treat with orthostatic intolerance...

Online survey of the use of Transcutaneous Nerve Stimulation for ME/CFS, 2022, Physios for MEDavid Strain has commented favourably about vagal stimulation and singing. I guess it depends what you are after.

Above, I mentioned that Hector Bonilla is suggesting that obesity is a predisposing factor in Long Covid. It's often tempting to point at risk factors that seem to be under the sick person's control. But, we need to know what the prevailing population rates are for these factors. wikipedia...

Abstract of that last paper that @Snow Leopard linked above.

Hector Bonilla, MD; Stanford University, Stanford, CA, USA R. Jane McKay, BSP. MD. FRCPC, FACP: British Columbia Women’s Hospital, University of British Columbia, Vancouver This session ran for an hour which was really too long, as basically no one has much in the way of concrete information...

Faroe Islands - mainly non-hospitalised cases. 94% followup of a prospective cohort. Looks like a decent study. I think this is more like the percentages we will see affected at 2 years than some of the figures that have been put about. It would be good if someone could assess these...

Day 1 of the conference starts today: IACFSME 2022 Virtual Medical Conference: Day 1 Workshops: 27 July (9 am to 5 pm EDT)

Thanks SNT Gatchaman. Dr Asad Khan makes some great points about the Long COVID-19 clinics. Have you heard anything about this that you can share?

(I should have said, thanks for coming here @Manuel.) I'm not discounting the main idea, even if the proposed risk haplotypes for ME/CFS don't pan out. But can we look at recent research on HLA alleles to see if they shed any light on that particular part of the proposal? Manuel's Table 1...

I had the impression that HLA alleles had been looked at in ME/CFS, and nothing had showed up with the frequency we would expect if these alleles were a major factor in ME/CFS susceptibility. I could well be wrong.

So, the media that has had human dendritic cells incubating in it (DCM) with viral dUTPase can make T cells differentiate to TFH cells. But do these TFH cells do anything much? Figure 5 Yes, they do. They produce a lot more IL-21. If they are re-stimulated with phorbol 12-myristate...

Figure 4B This team have been busy. So this experiment was back to the naive CD4+ T cells, cultured with anti-CD3/anti-CD28-coated beads (why those beads? I'm not sure at the moment). Then various things were added: 1. nothing - control 2. media that has had dendritic cells incubating in it...

Carrying on with this - Figure 4 Monocyte-derived human dendritic cells were stimulated with three different dUTPases for a day: 1. human dUTPase 2. HHV6-dUTPase 3. EBV-dUTPase and then the culture supernatant was assessed for activin A. The viral dUTPase clearly made the cells produce...

The other consultant: Dr Terry Segal I assume Crawley has had a hand in the creation of Segal's beliefs. Segal is part of the Clock consortium. CFS/ME is an 'adolescent problem'? Research interests include: Chronic fatigue syndrome Obesity Anorexia nervosa (medical aspects) Chronic medically...

One of the consultants: Dr Joanna Begent - among her specialties: Named Doctor for Child Safeguarding Specialist Child Safeguarding clinic for complex cases Families turning up for help with 'complex conditions' and being met with a specialist in child safeguarding. What's the chance the...