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There is a new thread to discuss the prevalence of co-morbidities in ME/CFS: Co-morbidities - prevalence in people with ME/CFS Some posts about the MEA survey and co-morbidity prevalence not related to EDS have been moved there

Gosh, this paper has a lot in it. Next up - can EBV and HHV-6A dUTPase proteins induce the secretion of regulators of the T cell differentiation? Well, yes, it seems they can. At this point, I think I need to know more about viral dUTPase. Brandon Cox and some of the other co-authors of this...

The next part of the study was to begin to find out 'what's in the ME/CFS serum that makes it different'? They looked at whether activin A was part of the story by adding follistatin-315 (FST), an activin inhibitor. Figure 3 B shows that the addition of FST did reduce the percentage of those T...

And the ME/CFS serum isn't just good at making PD-1 + CXCR5+ cells. The authors found that it was considerably better at making T cells expressing CD4+BCL6+ and BCL6+CXCR5+ than the control serum. The results are very nicely clustered, and there's a decent number of replicates.

The next bit of the study - testing to see what the ME/CFS sera can do! It took me a while to work this out. I didn't find the text very clear, but the Figure 2 caption helps a lot. So they took human naive CD4+ T cells and stimulated them with anti-CD3/CD28–coated beads 1. with nothing...

To me, it looks as though this team have some results in the Activin A and IL-21 levels well worth investigating further. But I'm not convinced by their suggestion that seropositivity of cases to antibodies against herpes virus dUTPases is related to action A and IL-21 levels:

So, what about IL-21, and the subset this 2022 study found with the stunningly high values? (around 100 pg/mL for the healthy cohort; with the disease subsets with around 20,000 pg/mL). We have looked at this paper with a POTS cohort: Inflammatory Biomarkers in [POTS] with Elevated...

Health Nerd gets it partly right, in that the research on Long Covid is awful, with loose questioning often scooping up a ridiculously high number of people into the Long Covid basket. But he thinks Long Covid is associated with more severe acute disease, and so the risk will decrease as...

One problem is that another study of activin A found normal levels in ME/CFS cases: We discussed that Lidbury paper here: Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis, 2017, Lidbury et al and here:Rethinking ME/CFS Diagnostic...

So, who has high activin A levels? Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study 2013 These authors thought high activin A levels were predictive of bad health outcomes and suggested they indicate inflammatory challenges...

Figure 1 - measures of activin A, IL-21 and CXCL13 in the sera of ME/CFS, GWI and healthy controls Those results look very interesting. Clearly, the increases in Activin A and IL-21 aren't happening in every person diagnosed with ME/CFS and GWI, but there does seem to be a significant...

Repeating the finding from this study, just because. :) No difference, even though the bias of subjects towards the treatment that was on offer must have been considerable with the ratio of completing self-selected participants to total possible sample population (around 9%, with most...

I see that it is possible to ask questions of the presenters, so, any forum member who won't be attending the conference, you can add your question to the relevant thread. Great to hear that you will be following some of the talks SNT Gatchaman.

This looks interesting, looks like quite a few of us missed it. Brandon Cox is presenting at the 2022 IACFS/ME conference.

This conference is on soon. We have four team members ready to work on providing notes on some of the presentations of this conference: @ahimsa, @Hutan, @ME/CFS Skeptic; @Trish. Thanks again to IACFSME for providing the free access. We've decided that we will create 4 threads, one for each day...

Thanks IC, changes made, see mod note in initial post.

PD-1 Programmed Cell Death Protein 1–Positive CD8+ T Cells in Multiple Sclerosis Exhausted Fighters or Peacekeepers. Jul 2022 It sounds complicated in MS: PD-1 might be present on t-cells in the central nervous system but not in the periphery. In-Depth Analysis of the Plasma Proteome in...

University of San Francisco team. It's a shame it isn't open access - I would have thought with the level of public funding for HIV/AIDS research, and in the public good, it could have been. Based on the abstract: The odds ratio of 4 for people with HIV getting PASC is interesting, although...

Sure, we can remain open-minded. But that doesn't mean assuming it's fine to apply the treatments in the absence of good reason and evidence. There's no evidence that "psychiatric treatment" cures ME/CFS so far, so there's no reason to apply it to people with ME/CFS outside of trials. CBT has...

( written at the end - Ugh, sorry, I'm boring even myself. Go and do something nice for yourself rather than bother with this.) I see that 65 people presented themselves for this 'psychotherapy in the workplace'. Only 23 ended up providing enough data. Cortisol Intervention had no impact on...