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Worth noting the samples aren't of the same type of people - most of those differences are highly significant. That's a really big difference in new onset of physical exhaustion (defined as a health condition) (risk difference 40% - 45.5% in the test-positive sample and 7.3% in the...

It's a great number of respondents, but self-selection looks to be a major problem.

I think you are right @Andy, but I wouldn't want anyone to feel shame for feeling shame. I think there are quite a lot of factors, including the exposure to gaslighting (or instead to good information) and the extent of reliance on others for practical support. I think everyone is concerned...

So yeah, where I was heading with the risk difference was that, say for depression, it looks as though having a Covid-19 infection is associated with an additional 1 person in one hundred getting a diagnosis of depression between 6 and 12 months after infection. I'm not sure that that is enough...

This risk difference thing Statistical notes for clinical researchers: Risk difference, risk ratio, and odds ratio So fatigue % at 6-12 months in Covid positive was 11.1% and in Covid negative was 3.1%. Then you just subtract one from the other, giving a risk difference of fatigue of 8%...

Something like this: The influence of posture duration on hand tremor during tasks with attention-distraction in persons with Parkinson’s disease In that case, drawing attention to the tremor can reduce or even stop it, and stress can increase tremor. I don't think it should be surprising...

It's hard to tell from the abstract exactly where this paper lands. I think it's good that they objectively assessed tremor in the three groups and assessed subjective reports of how bad people thought there tremor was. I think it's good that the researchers reported that people with FND were...

Most of the research about ME/CFS using animals has been egregiously bad - completely unlikely to generate any useful information, torturing the animals and then concluding things that could not fairly be concluded, leaving the ME/CFS research field muddier. It leaves me appalled at the humans...

Super

I think there's a new ethical approval for this study: https://clinicaltrials.gov/ct2/show/NCT05397626 Collaborator: Natural Wellness Now Health Products Responsible Party: Fred Friedberg, Stony Brook University The aim of this 10-week pilot study is to explore the potential benefit of two...

There's some statistical approaches there for assessing publication bias - if someone has the time to take us through those, it would be great.

I'd vote for that. Even better. This is such a useful paper cassava. It would have been great to refer to when we were trying to make the case to NICE that there was no good reason for CBT to hold such favoured state in the ME/CFS guideline. That recent paper that found that abdominal...

Yes, exactly right. In most successful struggles for major change that I can think of, there have been people who make a lot of noise and people who quietly negotiate a way forward. Both are needed, and sometimes the same people can do both. I think letters calling for more funding are...

Abstract COVID-19 is frequently accompanied by a hypercoagulable inflammatory state with microangiopathic pulmonary changes that can precede the diffuse alveolar damage characteristic of typical acute respiratory distress syndrome (ARDS) seen in other severe pathogenic infections. Parallels with...

I've only got as far as here so far, but I'm finding it a bit annoying. Baraniuk seems to define orthostatic intolerance as 'feeling dizzy or light headed'. So, some of the controls reported that they felt that way when they stood up. Some of the people with CFS reported feeling that way when...

David Oliver: Covid-19 and the Dunning-Kruger effect. 13 Jul 2022 I think this is the same David Oliver, recently writing an opinion in the BMJ.

There's a nice tweet in reply by Anil noting that ME/CFS is not chronic fatigue. Can someone invite Emma here? She clearly means well, but could use some more information (especially given she works 'day-to-day' with people with ME/CFS in the NHS).

Nature - Pathological sequelae of long-haul COVID by Mehandru, Merad, 2022 We talked about these possibilities and Mehandru's work on that thread.

I like the sound of this study, even though I'd normally be wary of PolyBio. Was this the study that Putrino and Proal didn't get funded by the NIH? If so, why didn't it get funded?

Gist is, if the itaconate shunt idea is correct, it makes the idea of a persistent infection more likely. So Ron's lab is working on finding a persistent infection (or at least something that looks like an infection to the body) and on finding out if the itaconate pathway is dysregulated. One...