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Thank you to you all Andy Devereux-Cooke, Sian Leary, Simon J. McGrath, Emma Northwood, Anna Redshaw, Charles Shepherd, Pippa Stacey, Claire Tripp, Jim Wilson, Margaret Mar, Danielle Boobyer, Sam Bromiley, Sonya Chowdhury, Claire Dransfield, Mohammed Almas, Øyvind Almelid, David Buchanan, Diana...

Links to Daisymay's posts about Colin Blakemore's role in the MRC and the idea of ME/CFS patients as dangerous activists: Blakemore also seems to have been instrumental in establishing the PACE trial. Dear Fiona, I think we are indeed prepared to be bolder and braver, thanks. The problems...

Indeed, Guillemin has come to our attention before. He co-authored this paper, also on the Kynurenine pathway The Role of Kynurenine Pathway and NAD + Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Dehhaghi et al which I see I described as "a naive and biased romp...

Still, my fatigue is substantially relieved by rest. I can be incapable of functioning, I have an afternoon sleep and then I can make a meal. I think it is a problem in the criteria.

Hospital has left my daughter in ME agony, claims mother July 17 2022 This is about poor care of severe ME/CFS in what seems to be a Leeds Hospital.

Indeed. But, if you believe ME/CFS is psychosomatic, then I guess it doesn't matter all that much what the treatment is. You go through the motions of treating the patient and, provided the treatment is convincing enough, the patient reports feeling better, and so, the job is done. One...

Well, I'm easily fatigued I guess, in that it's hard to walk and especially hard to walk up hills if I walk for any length of time. But, rest fixes the difficulty walking. Most mornings I wake up feeling a bit ill and exhausted. A bad day is when I have to retire to my bed for the afternoon...

Yes, sorry, I did get rather carried away last night. I had a coffee later than I should have, and then it was a nice change to see a study that might actually explain something after the bad Australian knyurenine paper. I liked that the findings with this paper seemed to be in line with other...

It's a nice presentation. I think the suggestions that Breanna makes at the end are important i.e. need a study with healthy controls. The way they have defined GI problems, I think most healthy women might experience GI problems, e.g. bloating, even if at just a low level. Also, I think they...

Yes, this does seem to be a well recognised thing. I recall cases particularly around Sydney, people develop an intolerance to meat due to tick bites. https://www.abc.net.au/news/2019-01-18/how-ticks-can-cause-mammalian-meat-allergy/10719136

That's pretty intensive CBT. Primary outcome - MFI-20 - fatigue Secondary outcomes - Overall efficacy evaluation - probably as good as any subjective measure - 4 levels - basically complete cure, nearly a cure, a significant improvement, and minimal or no change, also incorporating the MFI-20...

Th recognition that GET and CBT might not be effective treatments is good, although I'm not sure where the schizophrenia fits in. That's Friedberg F. ME/CFS: Primer for clinical practitioners. (2014). Available online at: www.iacfsme.org. (accessed July 2014). That primer should be withdrawn...

4 years later, I don't think we've seen any such study yet.

Whoops. No doubt there are other errors above. Past my bedtime.

This is for the whole ME/CFS sample versus all the controls. This sort of sounds good, but it's quite a bit of fiddling with the data. For example, I wonder how much race/ethnicity or even geography actually influenced metabolite levels, and if the adjustment process might have happened to...

The build up of those two compounds is consistent with the itaconate shunt hypothesis, because the itaconate stops the breakdown of succinate (and I think alpha-ketoglutarate is upstream of succinate). Itaconate shunt hypothesis video—Robert Phair

https://bscb.org/learning-resources/softcell-e-learning/peroxisome/ Acetyl-CoA is of course a neurotransmitter and is important in the TCA cycle. It possibly makes sense that if the cell goes into low energy mode, reducing energy production in the TCA cycle so that pathogens can't use the...

Some background: https://med-life.ca/plasmalogens Peroxisomes are organelles in the cell (the pink blobs). They make plasmalogens and acetyl-CoA and other things, and break down excess long chain fatty acids, uric acids and other things that might be a problem if they aren't broken down...

There's a lot of speculation and a number of things that are just plain wrong in that table in the Morris and Maes paper.

I've just got around to reading some of the paper. The abstract is a fair indication - it's a real mess of misinformation throughout. One of the authors, Gilles Guillemin was promoting the paper on Linked In as great team work, and I have to wonder, has he even read it? What for example has...