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Quinolinic acid (QA) is an NMDA receptor agonist, potentially neurotoxic, produced by microglia and macrophages in the brain during inflammation Xanthurenic acid (XA) is primarily produced in the brain, specifically within neurons ... do these 2 metabolites ring any bells? (I am too inexpert...

Non-scientist, I am struggling to see how HERV expression is involved in relevant (or any) disease pathways.

In an effort to understand this paper, I note their reference #69 is a thread here: which I commented on just now:

I understand little of this study (still trying, though...) , but it prompts questions: a) is HERV profile a potential MECFS diagnostic? b) do these T-cell profiles provide disease pathway clues? And @Hutan has provided great insight to one of their related papers "Over-representation of Torque...

Thanks so much @Utsikt and @jnmaciuch for your help.

Thanks very much - so hard to sort out fact from fiction, especially for a non-scientist like me. Could you point me to a study that concludes there is NO cortisol dysregulation? Is there a better way to find relevant papers than just ask Gemini or ChatGPT?

Is there evidence that MECFS causes dysregulated cortisol, or that the arrow of causality is reversed? Or if other systems eg immune are involved?

Responding to deleted post about scary movies causing heart rate to spike. But pwME allegedly have dampend/dysregulated cortisol feedback (prolonged, stuck in overdrive) vs scary-movie would involve more normal negative feedback (transient). Also pwME allegedly may have immune system...

Adrenalin really fits my wife's PEM - in addition to physical-effort-triggering (delayed in her early years, when she was unwittingly overdoing things; 25 years later, now moderate/severe, PEM is much more immediate), it also fits the speed/ease with which cognitive or emotional effort induces...

Given endogenous vs epipen adrenalin have different dosages, release patterns, delivery routes, associated hormones (epipen would have no associated cortisol or norepinephrine, etc ... is epipen response PEM-relevant?

Same comment - this preprint uses blood: "Can these blood/saliva studies give any useful information to the extent MECFS involves tissue-localised reactivation?"

Can these blood/saliva studies give any useful information to the extent MECFS involves tissue-localised reactivation?

How embarrasing ... I will sharpen my pencil in future.

This Lancet Europe article thinks: De we have someone who could ask Maureen Hansen?

As a relative newbie to s4me, this is my first encounter with David Systrom. No idea whether he is a good scientist, but he really knows how to explain things clearly. Reminds me of Audrey Ryback.

The video presentation of these protective SNPcombinations seems to have been prematurely curtailed for lack of time - a pity. Or perhaps a blessing given, on my cursory reading of the paper at any rate, that they did not identify specific protection mechanisms or insights ... just likely gene...

That 2019 "bipolar" paper says " In bipolar disorder hyperactivity is the main symptom of the manic phase, possibly reflecting faster signal transmission in the brain. Based on this assumption we have investigated genes related to the action potential, refractory period, ion channels and CNS...

PL filed a patent application which is, as usual, fairly impenetrable.

Late-comer to this thread though I am, and non-scientist to-boot, I have been trying to get to the bottom of this "combinatorial" approach. My take on it is to: a) enumerate all possible SNP combinations b) for each of these SNPcombinations: ... count Ca=#cases with it, and Co=#controls with...

Might this study not have considered performing a bi-directional MR analysis? Seems to me CFS could just as easily prompt a nice big chilli pizza washed down by a nice bottle of wine, rather than the other way around?