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From the above I am not clear that any of this explains anything relevant either to LongCovid or ME? I am afraid that a paper with Skull-Meninges-Brain Axis in the title says to me 'We are a group of people studying brainish things who know absolutely nothing about the rest of biology and will...

I have not read the full paper but I am unclear why they subjected healthy 'controls' to cryotherapy. I do not see how they provide a control. Normally the treatment has a control!

So it wasn't like asking three people @Trish cos you know it couldn't be Prince Charles. We have to be rigorous about our arguments here. Homeopathic royalty too dilute to exist is unlikely to be confused with pachyderms.

It's easy, functional medicine is the same as functional illness. There is nothing there except that it functions as if there was. Or, to be honest, it is a false belief in being medicine.

Nothing like break old ground with re-purposing then. The neurologists could have worked out what was going on in MS years ago but the same old memes kept going round and round. At least now people seem to understand that it might have something to do with B cells. (There was a clue -...

It is time that ME researchers actually said it how it is. It is not that the assay is not ready for clinical use. It has no apparent relevance to ME. A - value of 0.79 is impressive - you could bet on getting a result like this by chance and go home rich. More the laying of the turf over the...

CD16 monocytes are more likely to pick up virus simply by being older and having the immunoglobulin receptor (CD16) to bind virus complex. They are unlikely to continue in the circulation for more than a few days. All blood monocytes are young cells. They may live for years once they have got to...

The classification of 'non-classical monocytes' leaves me pretty sceptical. There are lots of these so called subset designations. But the crucial work done for me by Vikki Abrahams that led to our identification of targeting mechanisms in RA was on maturation of CD14+CD16- monocytes into CD16+...

Good thing Trish doesn't live in Thailand.

If a ventilation/perfusion study was not done originally, certainly. A pulmonary embolism can show nothing much on chest x-ray and other tests. Over a period of months the infarcted are of lung may scar. A later ventilation/perfusion study may show a persisting mismatch or a chest x-ray (or CT)...

And what if they have a disease called ME that does not show up on the virus-detection robot? Does it allow employers to prove that you are not ill! Be careful what you wish for sometimes.

That is a very fair critique of the biomedical science scene. I learnt early on how uncritical they are. A famous immunologist called Av Mitchison said to me I was foolish to think that there was any rational debate - I could see that that meant that only he could diss other people's stuff -...

AN interesting signalling system that might be relevant to ME.

I am all for studies of wearable biosensors but this seems a rather peculiar application. Are well all going to be wearing biosensors all the time to try to inhibit pandemics from now on? Maybe stopping people fiddling about with new viruses in labs might do more?

Apheresis for moving antibodies (as described here) usually uses a filter/adsorbing column based on a bacterium-derived antibody scavenging protein like Staph protein A. It specifically moves antibody a bit like an ion exchange resin removes specific salts. Old fashioned plasmapheresis I think...

I can see that if you are running you would want absorption of fluid in upper small intestine rather than colon so maybe that is the rationale.

I am always puzzled by these claims about rehydration. If I drink a pint of pure water I absorb it. I don't have watery diarrhoea, I have a pee after a bit - indicating it was absorbed. Same happens with beer (more often) which I gather usually has no glucose and only 0.004% sodium.

That would be 1.35% W/V. Sounds OK?

These people seem to be writing in the 4th century PT. (Post-truth that is.)

Alan Hakim was one of our trainees and took over the hypermobility story from Rodney Graham. He is probably now the main person in the UK pushing the make-believe about 'hEDS' or 'HSD'. The excerpts are typical. I think this is doing a huge amount of harm, particularly for children and...