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So at least we should perhaps be less concerned that the patients didn't have PEM. The low CCC rate is puzzling as you say but I have always thought CCC was too complicated. Nevertheless, one might expect 'barn door' ME cases to likely fit CCC. Is this correct though? They may have...

Looking at the article @Lucibee, I think this is OK. She sent me this 'quote' which was her paraphrase, and I said I thought it captured the message. The reason we cannot get out of bed with flu IS a brain problem rather than a muscle problem, as far as we know. It may be partly mediated by...

It may be for 'flu and the sequence of sentences is not ideal, but if the mechanism is driving symptoms in ME it IS a problem. We don't even know quite what it is protecting against in 'flu and it may well be unneeded there too. It may have evolved as a protective mechanism against food...

To me the whole problem here is that pWME will be thinking differently throughout the whole process simply because they know that they their disabilities are being studied. Controls will just be happily following instructions. I see no real possibility of extracting any conclusions from fMRI in...

Quite, the Stat News piece looks like the beginning of a trail of Chinese whispers drawing on whatever men is at hand.

I am not clear how effort preference differs from central fatigue but someone may be able to clarify that. Effort preference is clearly a bad term and hopefully will gain no traction. But I don't have a particular problem with the general sort of model they propose. Let us say that an...

Maybe one tangible step forward here is just the list of experts used by SMC. That must surely be a quantum change?

No. I don't see anything significantly new here. No, not as more than a possible pointer. But if there is a major difference in pathways in men and women it could show up with such small numbers. Take the analogy of inflammatory oligoarthritis in young adults. Take a random sample of 17. They...

The journal Nature that had a reputation for quality is a thing of the distant past. This is par for the course I am afraid.

I agree. The only hope maybe is that since this theory is a bit different from the old false beliefs one the BPS juggernaut cannot quite continue on the same tracks. But it is reminiscent of the Mark Edwards story about 'FND' that claims to use MRI data to explain mental processes. The comment...

I thought the same. I think the T cell populations they flagged up were those with more innate function. Nothing in what they or others have found would suggest a need to clear foreign antigen. This looks to me like pretty low level immunological analysis-by-meme.

As others have said, it all depends on the context. I picked up on the references to physical and not mental but within this presentation I thought nothing was out of step. ME is physical in the sense that all disease is, including schizophrenia and depression if you like. The point being made...

Interesting question. I Googled MS and PROMS and got this hit first. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326853/ It looks as if they don't work!

Another point maybe worth making is that prednisolone doses above 25mg daily produce a very significant high and sense of well being even if you weren't feeling unwell in the first place (as is the case for things like transplant conditioning). When the dose comes down there is a corresponding low.

Just a neat example of how much meaningless dross is out there in the literature. We have discussed all of those studies on the forum I think. None of them show anything very convincing. The complement abnormalities may pan out as something real but note that complement activation in the...

I personally think we can be 98% sure there is no inflammation in ME or Long Covid. Even with well documented B cell/antibody driven diseases the problem is not necessarily one of inflammation. The problem is aberrant signalling that may be mediated through immune pathways that normally would...

I thought it was very well done indeed. Merryn's mother, Sonya Chowdhury and Sean O'Neil were given the chance to be very clear and informative. The presenters seemed intelligent and sympathetic. The stuff on the history and politics was covered pretty well. I don't think one can ask for...

Anything from 5mg to 60mg daily and in those days maybe up to 120mg prednisolone equivalent per day for acute life threatening situations. Our trial compared 1000mg with 100mg given as three shots if I remember rightly. My memory from then and understanding since is that the high dose 1000mg...

Our experience with 1000mg pulses of prednisolone in lupus was that there was no advantage over standard dosage. As Trish says, I hope you are under close supervision. High dose prednisolone is quite high risk, the most common problem being major gastrointestinal haemorrhage.

Sure, but the FND category can only increase the chance of missing stuff. I think it is reasonable to say that people with problems of this sort, on careful assessment, can be told that even though we have no real idea what is causing the problem in the majority of similar cases no progressive...