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Do you have a source for the minimum 12 hours delay? I've taken a look at the CCC and IOM 2015 diagnostic criteria, as well as the CDC and NICE guidelines and it's not defined as such anywhere that I've seen. Maybe you're confused because sometimes PEM is characterised as symptoms "typically"...

Small overexertions can cause me to overheat too honestly. Interesting point. I do very poor with both being too cold and with being too hot. But I generally get too cold way easier, than too hot. So I'm more comfortable in summer. Then again the season doesn't doesn't significantly impact my...

Does Wüst’s work have any relevance here? Edit: I guess we're still waiting on the ME/CFS data?

I've mainly heard that people feel better on the onset of an infection and maybe during if it was a very mild one (although for me this is not a very noticeable effect). Having a flu or any infection that causes a fever usually wipes me out for 2+ weeks and relatively often leads to a decline in...

I mean the guideline for adults also isn't updated yet. Hopefully it's done next year and children's guideline will follow. NKCV is also still doing whatever the hell they want.. But yeah it's ridiculous. It's been 7 years.

True, but I feel like you might have a more unbiased look. Maybe I will start a thread at some point to look for some more opinions.

That's too bad. It's one of the things I'm really curious about. I've been trying to figure it out for a long time (how it works for myself) because it's a pretty prominent symptom for me. If you ever manage to tie this into a hypothesis I would love to hear it. Do you think it could be more...

No worries, we do seem to be getting there. That's a fun analogy, happy to hear it fits theoretically! I'm still very curious on the involvement of the sympathetic nervous system when trying to push through: @Jonathan Edwards any idea how that could work?

So could that responsiveness also directly cause symptoms on exertion (feeling depleted), rather than it being delayed like in PEM? Because to me there's a bit of distinction there. The depletion feeling feels more like a warning to stop and doesn't really include the malaise symptom like in...

@Jonathan Edwards let me know if I should stop tagging you on unanswered questions but I'll take my chances for now haha. In the context of your hypothesis I think the part we talked about previously makes sense. Stress hormones can make us feel better and able to do more by overriding signals...

Thanks for the kind words. I've spent a lot of times thinking, experimenting and analyzing my symptoms lol. Also good to hear others have similar experiences. It's interesting because I've also read experiences of people that do not get any symptoms when overexerting and only get delayed...

For sure! That's a shame.

That's really great to see, he did his research. Where was this published?

It would be really ironic indeed. I do like the theory the more I think about it. It fits witht the symptoms and would expain why it's been so hard to find abnormalities. It would be real nice if we knew more about sickness behaviour.. There's another symptom of mine of which I wonder about...

Do we know why that is? And where along the chain such activity is inhibited?

Seems like the results are not ordered chronologically. For me it's the third result.

I liked the summary by @ME/CFS Skeptic:

I've been on Lexapro for 2 years now. Doesn't help with fatigue but helps me a lot with mood and just makes being so sick more manageable.

I do want to note that athletes sometimes track morning resting HR and it being higher than normal is used as in indication of overreaching and to avoid overtraining. My point being, elevated morning resting HR is also seen in healthy people when pushing their limits. Now how much the above is...

Thanks for posting @forestglip, you were fast haha! I was thinking there was some relevance to your hypothesis! Post-COVID from what I've seen is a newer term to denote Long Covid with more emphasis on the fact that it's not "long-lasting Covid" but instead a Post-acute infection syndrome ->...