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I may be repeating some points already made. Started drafting this answer offline and then the power went off for a loooong 9 hours - and a lot of discussion seems to have happened in that time. I'm pleased you put that. It needs to be spelled out very clearly for those not familiar with PEM...

This. Because too few have been interested enough to even try to have a look. Plus different people use the terms differently, to ensure maximum confusion. These are some of the interpretations I've come across and can recall at the top of my head; there are likely to be others. No idea which...

This seems to be what they're proposing to develop: https://www.icf-research-branch.org/icf-based-documentation-form Currently there only seem to be ICF core sets for a limited number of conditions. I had a play with the electronic documentation form tool (see link in quote), using MS as an...

Impressive work @Michiel Tack :emoji_thumbsup: Decidedly unimpressive response from Cochrane :emoji_thumbsdown:

Lily Chu making sense, as usual.

A more nuanced review of placebo. Have only skimmed it, so my summary may be a bit off. The gist seems to be that under certain conditions, some placebos do create a physiological response. Mostly this requires pre-conditioning with an active intervention first, so if you've been using oxygen...

I think the key here is that it's not measuring fatigue itself, it's measuring the impact of fatigue. To my mind, what this MS Fatigue Impact scale highlights yet again is how differently we are being treated to people with diseases like MS. There isn't all that much wrong with any of the...

Can somebody explain figure 2B and the text relating to it? So the text says no significant difference in muscle fibre generated mitochondrial superoxide, neither with nor without addition of a nitric oxide synthetase inhibitor. Yet the graphs seem to show a difference. Figure 2B shows complete...

To be fair it is vastly better than it was, which was utterly appalling. Still not good, exactly - the exercise bit is way too garbled for that - but apart from that it now roughly aligns with IOM/NAM. Baby steps.

Ha ha. I often say that if only I could remember all the things I have 'learnt' listening to podcasts I'd be a very wise person by now. Alas...

Is there a way of testing metabolic profiles in those different microenvironments?

This thread has gone a bit quiet. Let's see if we can revive it. I'm currently binge-listening to the "Subtitle" podcast. Just a few of the topics, the range is wide and the concept of 'language' interpreted loosely: "Subtitle" is part of the Hub & Spoke stable of podcasts...

In one of those weird coincidences, while NZ health authorities were circling around that cool store at the centre of our latest outbreak I was listening to an audiobook recounting several people's childhood memories from Greenland. What's the connection you might ask. Well, one of the...

Of historical but also current interest. Article based on as yet unpublished research. For context, the population back the was about 1.6 billion (according to worldometers.info), so roughly equivalent to nearly 5 million dying today...

Patients were involved in reviewing this prior to publication. One of them was Paul Garner - I don't recognise any of the other names - he may well be reponsible for the bolding of "if tolerated".

More discussion on the same topic and links to some other scales (both PEM and more general ones): https://www.s4me.info/threads/defining-and-measuring-post-exertional-malaise-a-discussion.15783/

There was an interview on NZ radio today. No mention of ME. Part of it about the long hauler phenomenon that hasn't had much media attention in NZ to date, the other part about the Survivor Corps in the US which is primarily a vehicle to encourage recovered patients to donate plasma and partly a...

Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand Jemma L Geoghegan et al Preprint Aug 2020 https://www.medrxiv.org/content/10.1101/2020.08.05.20168930v2 And to mark 100 days without community transmission - how long can this lucky streak...

This may account for the fact that nearly 20% did not report PEM. At least this was recorded and it turns out that the non-PEM cases cluster in some of the subgroups. Which could possibly tell us something but what that might be isn't further analysed. Seems like a missed opportunity. I'd like...

Weird phrasing all right. Based on the article it looks like something got lost in translation between mental concept and the written expression of it. This is a Preprint. Can they still fix it? That's good to hear. This could be a useful addition to the toolkit. Of course no single device is...