Search results

OK, that suggests that, as one might suspect, results can be affected by factors other than the inherent biochemical capacity of muscle tissue. That is why I wonder if the change in 2 day CPET in ME is actually measuring a metabolic change or is reflecting a signalling event that both generates...

There is a particular difficulty if a potential side effect of a treatment is exacerbation of the pre-existing problem. For most drug side effects the effect is something rather rarely encountered in the treated population. Most people with a cough do not have a widespread itchy rash suddenly...

There is a particular difficulty if a potential side effect of a treatment is exacerbation of the pre-existing problem. For most drug side effects the effect is something rather rarely encountered in the treated population. Most people with a cough do not have a widespread itchy rash suddenly...

I don't now. I am actually sceptical that 'training' can occur in 24hrs. Cardiac output is not going to improve in that time, for instance. I would like to understand the physiology better but I find the way these studies are written up very opaque.

@alex3619, like @Esther12 I am not aware of any studies that show actual harm, in the sense of long term deterioration being shown to be caused by exercise. A decrease in exercise capacity in response to exertion over a two day period does not indicate harm. Training with eccentric muscle usage...

@alex3619, like @Esther12 I am not aware of any studies that show actual harm, in the sense of long term deterioration being shown to be caused by exercise. A decrease in exercise capacity in response to exertion over a two day period does not indicate harm. Training with eccentric muscle usage...

Fair comment. It is confusing. Most people, including many ME activists, conflate CFS and ME into CFS/ME. I personally do not regard them as identical as there appear to be some different symptoms. Neither did the PACE paper. But is a tricky area that needs clarifying. This suggests the man...

The question was fair. Muscle disease is a tiny subspecialty including muscular dystrophies, myositis and not much else. Telling someone with Duchenne muscular dystrophy to accept their fate and commit themselves to feats their muscles cannot achieve seems likely to go down like a lead balloon...

A lesion just means a physical abnormality of a particular domain of tissue. So if a channelopathy is producing symptoms there is a lesion somewhere, even if the term might not be used in that context very often - because the abnormality may be very diffuse. To say there is a lesion of a...

This may be a reasonably common response but I thinking the vast majority of cases the response is more sensible. It is that if there is no evidence of lesions in the parts of the nervous system where we understand clearly the relations between structure, connections and function then we have to...

Neurological-type symptoms often occur without evidence of a nerve lesion. But if a pattern of symptoms has not been found to correlate with evidence of a nerve lesion on objective investigation then there is no reason to use it as an indicator of such a lesion. So I am not sure the point of...

As I understand it that is not what the term was coined to mean. Ramsay did not coin the term. And as you say, Ramsay muddles the two up.

Medical terms change their meaning with time just like other words in a language. Myalgic encephalomyelitis does not actually come from RFH but from a shared speculation by certain infectious disease physicians and epidemiologists that there might be a new febrile illness with neurological...

I think that proposition is pretty sound. An acute febrile illness with apparent neurological signs suggestive of neuropathy, monoplegia, ocular and facial palsy bears no resemblance to the chronic syndrome of ME.

When I used it I was not implying hysteria. If hysteria implies secondary gain and conversion then definitely not. Jenkins's account is problematic because it talks of spread of 'hysterical symptoms'. Does that mean symptoms due to hysteria or the sort of symptoms that one also sees in hysteria...

By 'those analysing' I was really referring to those that McE and B refer to as dismissing hysteria. And McE and B quote an active dismissal, not just a never ruling on. I wouldn't put too much weight on district nurses saying they had seen cases too. In medicine one is bombarded with cases of...

If there was ever any doubt about how poor Dr Chalder's clinical trial work is, here it is again. Now we have overt faith healing - you have to accept and commit. Where does the capital S in MuScle come from? Surely this is a Freudian reference to MUS. You could not make this up.

I think it is sufficient to propose a slightly differently worded hypothesis from McE and B, namely that 'suggestibility' or other subjective factors altering symptom presentation was not ruled out by those analysing the outbreaks. McE and B wade in with 'hysteria' but their idea of hysteria...

That is certainly how I see it. McE and B have done a huge amount of harm despite the fact that their conclusions on acute illnesses in outbreaks are irrelevant to the problem of ME as now defined.

I think McE and B give a pretty good case for ruling out neurological pathology for the symptoms they analysed. They tell us that all neurophysiological studies were normal - i.e. objective tests of nerves showed normal function. Acute febrile delirium is a sort of neuropathology but that does...