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The relevant point I think is that we do not have sufficient evidence to be able to say anything useful about the causation of ME, other than it must be consistent with the epidemiological data on gender ratio and ages of presentation. So no credible mechanism can be excluded. That said, I am...

Well, that shouldn't take a minute to organise, then.

Seems a bit like these self-driving car thingies. Try it out on the road and run a few people over before you see if you know what you are doing. Or to extend the poker metaphor raising the stakes on a pair of threes - and saying so.

The stakes seem to be getting higher every week. Fortunately it seems that some people are showing their hand. I think I may have a lot of reading to do but I get the distinct impression that my distinct impression that 'evidence-based' talking therapies are all based on stuff as bad as PACE is...

I heard you, @Trish.

The weird thing is that I was sure that Chalmers and Glasziou paper was recent.

Gossip is gossip, even in the BMJ office.

But maybe the BMJ blog software will still see my post, since it is posted?

Ah! I see this is 4 years old. I suspect my comment will not get posted!

Well flagged @Sasha. So I posted this: For me there is a deep irony here. I was recently pointed to the Chalmers and Glasziou article. What was so strange was that I had shortly before been asked to give an opinion on a manuscript involving one of these authors that appeared to show a total...

Dear @Liv aka Mrs Sowester, If it were a matter of reaching out to ordinary people I can see that make sense. But my concern here is a purely pragmatic one. Parents reaching out to paediatricians emotionally is pretty guaranteed to confirm the paediatrician's prejudice that the BPS people are...

I wonder if this is a genetic thing. You know, children of people who believe that if it is their football only they are allowed to score goals tend to believe this even more?

Looking him up is quite a hoot. https://www.telegraph.co.uk/education/2018/03/16/kings-college-london-accused-no-platforming-itsown-lecturer/ Apparently his book was subtitled 'how state benefits affect personality'. Lovely guy. He thinks people on benefits should not have so many children.

Oh, yes I think so. Last time I think it was Harry and the veterans? Before that it was his dad or brother - I forget. And William has just been made an honorary fellow of Royal Society of Medicine by Wessely. (Don't tell anyone but anyone can be a 'fellow' of the RSM by paying £200 a year or...

In this quote 'my diary' simply means my schedule - where I am going to be when and what for. I suspect he is referring to the fact that people are mentioning conferences he is posted to talk at or concerts where he might have been seen on the terrace or ... photoshoots with members of the Royal...

I am going to stick my neck out here. I looked at the new edition of the purple book this weekend. Although it is unintentional I think the presentation may tend to encourage people to go down the sort of line of argument in the letter here. There are masses of references to scientific papers...

I would add that finding T cell clonal expansion within diseased tissues as in MS or rheumatic fever is a completely different thing from finding clonal expansion in circulating cells. Clonal expansion will occur in diseased tissue simply because the T cells that arrive there divide if activated...

The mechanism to avoid self-attack is that the thymus has a system for presenting all self peptides to immature T cells and deleting those that recognise self. A defect in this system occurs in the very rare condition where there is a mutation in a gene called AIRE. However, this is an extremely...

Too bad then that Drs Wessely, Sharpe and Co have taken to using exactly these tactics to contact employers of those who have annoyed them. Talk about pots and kettles. I was talking to someone recently who said that Ben Goldacre goes in for this sort of thing quite a lot -writing to editors...

But the irony is that nobody knows what skill or proper training mean here. No comparison has been done - except the one between King's and Holland where it seemed that King's wasn't much cop if I remember rightly!