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I disagree with Willy Weir on this. I think things a lot more complicated. Fearful thoughts can lead to major shifts in autonomic function that can change cellular behaviour significantly in the short term. In the longer terms various thoughts leading to patterns of behaviour can change all...

We know the bottom of the success stories. Some people get better and it is highly likely that some of these will have had some CBT or GET shortly beforehand. We expect these stories to exist. But as anecdotes they provide no evidence for causal link between treatment and improvement - the whole...

I think that was probably fair enough. It takes hours for vaccine components to get to the immune system. Even the toxins in old fashioned typhoid vaccine took more than 10 minutes to get into the circulation. Faints with seizures are common enough following injections but they are due to...

I think there is a problem, perhaps particularly in the UK, with medically qualified advocates for ME over-egging the evidence for viruses, vaccines, mitochondria or whatever. The early critiques of the PACE trial were heavily overlain with arguments about how the condition could not be...

New fiends are always helpful. It's the old ones that are the problem.

I don't know what scientific explanations are offered in the literature but I can confirm the existence of the sort of problem you describe. The only time I took zopiclone after perhaps two doses I felt seriously dysphoric, anxious, agitated, irrational and under the impression that I was having...

I find it very hard to work out what these numbers mean. As it stands the abstract seems totally misleading. Whatever the numbers I don't think one sample tells us anything useful.

I think that is right - the idea that blinding removes the possibility of a placebo effect is just garble. Although if by 'placebo effect' we include all the factors that give overoptimistic assessments of responses in trials, including what is often called the reverse placebo effect where it is...

Thanks,it reveals that he has no clue about the difference between what is done and what is adequate. He has no power of critical thinking.

It seems not.

I wasn't invited to this so I don't know much about it. I would be interested to hear what Angela Vincent has to say about neuronal antibodies.

Sorry kd, I think it is a statement of reality alright. Who is kd?

It might be interesting to see how many times internet sites carrying the PACE paper (PubMed etc) have been downloaded recently. It might turn out that rather a lot of people have read the paper!

I don't see how anyone can charge for a Chalder fatigue score. You might have to pay for software to calculate the score I suppose if you wanted to get scores rapidly in clinic. However, I don't think these scores are of any real relevance to routine clinical use. They might be useful for audit...

Nobody

I don't think there is an 'art of reviewing'. Reviewing is just giving an honest opinion. It is not unreasonable that senior people are asked to review if you have a system as at present. My idea is that you do not have formal prepublication review. You post your paper on your university website...

Holton claims that the picture here looks simplistic, but we do not yet have evidence that would give us sufficient reason to abandon it. Or to even take it seriously? The more I think about these things the more it all seems similar to homeopathy. The idea of treating like with like, although...

I prefer double unblinded review and publication of the review and reviewer attached to the paper. Then if the reviewer says anything stupid or irrelevant or vindictive it is apparent for all to see. PLOS One already has something a bit like this.

I think we wait to hear what the final scoping agenda is. We also wait for adverts asking for applications for committee places.

There is a difference between putting something in the guideline as a positive suggestion and what physicians are free to use if they wish. I don't think mestinon should be suggested specifically but if a physician feels they are justified in using it they can now and will still be able to...