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Of course in that thread, there is some guy telling Kate that the solution is to walk/jog 10,000 steps per day. :confused:

Psychosocial factors certainly affect the reporting of symptoms on symptom questionnaires as stated in the conclusion, so without objective signs of symptoms or their impact (actigraphy etc), the results are inconclusive. As @Hutan suggests, this is a post-hoc analysis and therefore is...

The slightly elevated cytokines (IL-6) etc are typical of acute infections with some inflammation and don't suggest a "cytokine storm" syndrome, where cytokine levels are extremely high (hyperinflammation). See this commentary also: https://www.medpagetoday.com/infectiousdisease/covid19/86021...

Indeed, but it shows some relationship between thermoregulation, vascular regulation and exhaustion which may be interesting (if not applicable to ME or CFS).

Note that a lower p50mito means the mitochondria have greater oxygen affinity, which reflects excess respiration capacity. Unless the participant has a severe disease, VO2Max is always limited by the vascular system, namely the amount of oxygen that can be delivered to the muscle. Mitochondrial...

From 2018, David M. Systrom interviewed by Llewellyn King.

Notably the study revealed that 99% of patients seroconverted, a number of people are being falsely diagnosed with COVID19 (they probably have other viral infections), and the usual accuracy limitations of the tests. The fact that viral fragments continue to be detected is not atypical of...

The problem is that doctors are classically trained to believe that disease is due to damage (lesions), rather than systemic dysregulation. Many don't appreciate that the lesion is often a symptom, not the cause. In addition to the need for repair of lung tissue, there is likely significant...

The primers are supposed to be quite specific to the virus, but the specificity of a PCR test is not just based on the primers/probes, but everything else that can accidentally go wrong. https://pubs.rsna.org/doi/10.1148/radiol.2020201343

Hi, I apologise for not replying sooner, I missed this post earlier. This study does provide suggestive quality evidence that asymptomatic transmission is possible and suggests the importance of larger scale studies to confirm. There was a range of sampling times for the first survey: 8 new...

Covid-19: Confidentiality agreements allow antibody test manufacturers to withhold evaluation results https://www.bmj.com/content/369/bmj.m1816

Those figures are far higher than real-world test results of similar tests and I simply won't believe them unless they publish a large scale community study comparing the test to other diagnostic tests such as RT-PCR, CT scanning and a symptom based diagnostic protocol. The problem with their...

"Accuracy" is a misleading figure, because it doesn't say whether the inaccuracy was due to false positives or negatives. The assumption of 99.5% specificity was from a previous meta analysis of RT-PCR studies. The difference in the figures is due to the fact that many of the subjects are not...

Yes, with 99.5% specificity, we would only expect 6-7 of the 98 positives to be false positives. (from Bayes' Theorem). The ratio of false to true positives of a study like this is likely to be lower because it is a selected population with a known risk factor. But not reporting symptoms at the...

They did not measure viral shedding prospectively, it is merely "inferred" (hypothesised) as stated in the abstract.

There were no statistical differences in corticosteroid use between the patient and placebo groups (numerically, slightly higher in placebo group). The US study may well have allowed patients to use corticosteroids too. Note that the US study changed their primary outcome (from published...

I think the shift in virulence is a microevolutionary dance between the viruses and their hosts - as the hosts change their behaviour (and use treatments etc.) and develop immunity from exposure to prior versions of the virus, the virus adapts. This can lead to oscillatory patterns. I think...

How do we know this? It is frequently hypothesised, but never demonstrated. (note, it is important not to misinterpret raw test results without considering sensitivity and specificity...)

Yes.

She was willing and highly compliant, yet she is still ill at the end. The conclusion is horrifying, namely all they are interested in Sally's return to work, without considering the impact that this would have on the rest of her life - the fact that she wanted to cut her hours suggests she is...