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The key point is that muscular capillary function is not controlled by central nerves like Arteries and veins, but regulated locally to maintain a constant-flow condition (variable pressure). It is already known that KATP channels play a key role. Some more discussion here...

No. Regardless of whether the immune system thinks the bug is gone or not, there will still be IgG floating around (in circulation) due to the prior infection.

Not yet. But the serological tests have around a 90% sensitivity several months down the track. This can be due to, but isn't necessarily due to a lack of antibodies, but a failure of the assay to detect all types of antibodies to the pathogen. When you have thousands of people with an illness...

This model has far too many unverified assumptions to be any more than suggestive. Other models could just have likely predicted or assumed more undetected cases in late Jan/early Feb - not just in the USA, but Europe too. I would consider airports themselves as prime candidates for...

Yes, but this bit still grates for me: There is much we do know, from research on SARS-1, ME and other post-viral illnesses, yet almost everyone is ignorant of this because they never bothered to read the research before SARS-2 and few are bothering to read it even now. COVID-19 is far less...

Pleasantly surprised by those replies, Arvind Joshi in particular...

I had the same reaction. 8000 steps, wow! 5200 steps is around 4 km! I could do 5000 steps maybe once a week if I were to rest for the next few days!

Our nerves do not function quickly enough for motor control feedback to occur in real-time, hence we have a predictive model of motor control (partially located to the supplementary motor area of the brain). Without this model, we would not be able to precisely control the force and location of...

More on this, one of the models is described here: https://www.frontiersin.org/articles/10.3389/fnhum.2016.00550/full The nonsense is revealed in figure 6 where "prior precision of the homeostatic belief is increased from 1 to 4. As a consequence, when a perturbation occurs at (6), this yields...

Yes, it is tricky if the lockdown/social distancing/economic factors are reducing deaths due to other reasons like traffic reduced collisions as you mention. There is no "control" lockdown, that we can see what impact lockdowns have on deaths in the absence of an endemic virus... I agree that...

The stuff you summarised is not controversial, and is considered a key part of our understanding of proprioception as explained: https://en.wikipedia.org/wiki/Efference_copy It is the notions of allostasis (borrowed from Noakes) and the weird attentional feedback loop that leads to an...

I just lost a long detailed reply to this thread, sigh. I'll try to be more concise this time I guess. The author seems to be basing his ideas on this: https://pubmed.ncbi.nlm.nih.gov/22641838/ Overall, the article is poorly focused and has a confused understanding of effort perception...

I think it is possible to misinterpret what they are saying. Unless people are physically being turned away or never getting results, there are no functional capacity limits. Note that in the link you provided, they state the local "capacity limit" was 48,000, which was lower than the number of...

I don't entertain the idea that he has changed his opinions since: https://www.researchgate.net/publication/323130400_Fatigue_Is_Associated_With_Altered_Monitoring_and_Preparation_of_Physical_Effort_in_Patients_With_Chronic_Fatigue_Syndrome The whole discussion section simply assumes (as a...

It's noteworthy that Wessely admitted GET is just another form of CBT. This is obvious to anyone who actually has an understanding of exercise physiology and has looked at the protocol(s), yet many (especially medical practitioners who should know better) think that GET is about exercise and...

She certainly was. Some of us still remember this paper she co-authored with Wessely, where they promote the idea that the health complaints of a certain demographic (middle class women) should be dismissed by medical practitioners. https://academic.oup.com/bmb/article/69/1/197/523356

And supervisor for @Hilda Bastian's PhD https://iebh.bond.edu.au/education-services/hdr-students-and-opportunities (completions in 2020)

Glad they published, but I still didn't find this particularly enlightening with regards to any specific hypotheses. The concepts like "aberrant homeostasis" and "multi-spiraling disease course" apply to pretty much all chronic diseases. Doctors have long mistaken lesions (tissue damage) with...

Perhaps the author was someone who has experience as a staffer for a politician. ;)

A key point is that, significant myocarditis or other heart damage (or neurological damage) is not typical in Long-COVID patients either. Without strong (prospective population-based) epidemiological studies of post-viral consequences, it is impossible to form any conclusions. There is an...