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  1. Snow Leopard

    SMC: Advice for Researchers Experiencing Harassment

    Yes, the timing seems to be forming a bit of a pattern now.
  2. Snow Leopard

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome', Larun et al. - New version October 2019 and new date December 2024

    It is notable that the main conclusion which was a sticking point for David Tovey, namely downgrading the evidence from "probably" to "may" and from "moderate" to "low-moderate" has not made it into the revised article. (See the FOI correspondence on 29th of May) I suggest this is a point of...
  3. Snow Leopard

    United Kingdom: Science Media Centre (including Fiona Fox)

    Interesting. Fox does indeed mention Finn in this article: https://www.sciencemediacentre.org/beware-creating-fake-news-on-mmr/ Which I largely agree with - remember that the proportion of 5 year olds who have had at least one MMR dose is 94.9%, only 0.1% from the highs - those who only receive...
  4. Snow Leopard

    Comments Simon Wessely revisits some of his early work on chronic fatigue syndrome, journal article (2012) Wessely

    The most ridiculous part is the fact that people are jumping to far reaching conclusions based on sloppy questionnaires.
  5. Snow Leopard

    A general thread on the PACE trial!

    It's approximate. The rest, above and below the middle 68% (100-68)/2 https://www.mathsisfun.com/data/standard-normal-distribution-table.html (try the Z onwards setting)
  6. Snow Leopard

    Comments Simon Wessely revisits some of his early work on chronic fatigue syndrome, journal article (2012) Wessely

    There are two conclusions one can form after reading Wessely's study the first is there is little difference between depression and CFS. The second is the questionnaire lacks relevance or specificity. Now if the questionnaire was designed by asking patients what is relevant and associated...
  7. Snow Leopard

    A general thread on the PACE trial!

    This brings home the point. By "normal" they meant within or above 1 SD of normal, which assuming a gaussian distribution would be the top 84% (68+16) of the population. Using the actual distribution in the graph above, this would mean a PF function cutoff somewhere around 82-84. Meaning they...
  8. Snow Leopard

    Dr Ron Davis - Updates on ME/CFS research - September 2019 onwards

    That isn't the only one they initially looked at though. So you have to correct for multiple comparisons and the odds go way down. When 90% (or whatever) of the general population has the SNP, at best it is clear the SNP is not the most important part. I don't know why the gene testing is...
  9. Snow Leopard

    United Kingdom: Science Media Centre (including Fiona Fox)

    Or quality... Those professionals who think it is unimportant to critically read the method and results of a study, when you can just read the discussion and conclusion.
  10. Snow Leopard

    SMILE trial data to be released

    There is no magic cutoff, because it is a self report questionnaire with limited scope. In the real world, data like this is not clean. It's not just the potential for missing data but deliberate behaviour in answering the questionnaire in biased ways. It's quite possible to deliberately...
  11. Snow Leopard

    United Kingdom: Science Media Centre (including Fiona Fox)

    It's officially give awards to your mates season again!
  12. Snow Leopard

    Dr Ron Davis - Updates on ME/CFS research - September 2019 onwards

    The problem is there are hundreds if not thousands of possibilities that fit that criteria.
  13. Snow Leopard

    Comment: Psychiatry’s stance towards scientifically implausible therapies: are we losing ground?, 2019, Rosen et al

    This is true, but I think the overall point remains - a Randomised Controlled (blinded comparison group) Trial is the minimum level of evidence and we need more evidence to determine the relevance. The classical examples are the use of antidepressants. We don't really know why they are...
  14. Snow Leopard

    RoB 2: a revised tool for assessing risk of bias in randomised trials (2019) Sterne et al.

    I think Larun's argument is ridiculous because the patients who really don't like GET would never consent to participate in such a trial in the first place. Participants who are willing to participate in such a trial likely have "an open mind" if you know what I mean and even if they have...
  15. Snow Leopard

    Validation of the Pittsburgh Fatigability Scale in a mixed sample of adults with and without chronic conditions, 2019, Carlozzi et al

    They still haven't bothered to ask patients with specific illnesses (and different backgrounds) whether these questions are understandable/easily answered and relevant.
  16. Snow Leopard

    Scales which measure disease severity

    I've had a lot of trouble trying to pin that down before...
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