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The manuscript is decent but if you can't achieve significance with 49/48 patients, well, I doubt the therapy is very good.

See also: What is “evidence” in psychotherapies? Scott O. Lilienfeld https://onlinelibrary.wiley.com/doi/full/10.1002/wps.20654?af=R

Despite all the rhetoric, rates of antivaxxers are not increasing and vaccination rates are at or near all time highs in almost all countries around the world. Those countries with lower vaccination rates have had severe vaccine shortages and other health system crises (Philippines, Ukraine -...

Sure, "pragmatic" trials can only ever be considered 'suggestive' quality evidence (along with case studies and pilot studies). The question is why do professionals assume that these trials can be considered 'moderately conclusive' quality evidence?

Most likely explanation is that it is a coincidence, with natural remission. I'd be very sceptical of anything less than a blinded pilot study.

There was substantial drop out rates, it is hard to say if this biased the results. I don't understand why they didn't include T2 results in Table 2? Why would you only publish half the results of a crossover trial? It suggests to me that something is not quite right. If physical activity...

So you've been talking to another Snow Leopard behind my back!?! :jawdrop: What are friends for, if not giving fake awards?

If professionals aren't serving the needs of their clients, then who are they serving?

Getting your mates to award you a prize is a great idea! Looking forward to my 'best talking snow leopard' award from you guys!

NICE won't change their mind until the article is retracted. I'd bet a reasonable amount of money on it. Those in charge of government policy want to be seen as doing something. They expect to receive more criticism if they recommend nothing, compared to doing something ineffective. Their...

Nope. The average medical practitioner (for example, the GP I saw who looked up CFS on Wikipedia) does not look very deep at the evidence and still expects the Cochrane brand to do the thinking for them.

I wonder, do these authors intend to publish this in a scholarly journal?

No news is good news?

They're afraid of the big loss of face, namely they'd have to admit they had an article up for years that didn't meet their quality standards. They also no doubt have certain UK and Dutch psychiatrists in their ears about how terrible it would be to give ammunition to the skeptical patient...

The issue is that the (former) editor was demanding changes or a voluntary retraction by the authors (to avoid loss of face for both the journal and the authors), yet the authors were unwilling to do either, presumably because they knew the editor was retiring and they may get a different...

Extraordinary claims require extraordinary evidence... The woman in that phantom pain case study had a hand previously and the burning pain could well have resulted after there was peripheral regeneration of the nerves formerly connected to the hand, leading to sensitivity to things they...

Hi all, keep in mind, the author of this paper is a disciple of Ted Kaptchuk and his "powerful placebo" pseudoscience. https://onlinelibrary.wiley.com/doi/10.1002/ana.25387 (Burke and Kaptchuk) http://www.tmslab.org/tms%20class%20slides/067.pdf (PLACEBO EFFECTS & TRANSCRANIAL MAGNETIC...

I don't understand, are they retrospectively trying to block access to those two documents?

No, they're saying they aren't going to include trials without a comparison group (eg "treatment as usual"). What is notable is not that they discard noncomparitive studies, but rather they're willing to include studies that have comparison groups that aren't control groups.

If you want to claim that, you have to test it with a model - how much of the variance does it predict? How sensitive and specific is the predictor? They do matter, but they aren't necessarily the most important factor at peak exertion. Keep in mind that the body tries to buffer the effects of...