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Inflammatory cytokines are not associated with (reported) fatigue in Sjögren’s syndrome either... https://link.springer.com/article/10.1007/s00296-019-04354-0 Fact is, cytokines are not a biomarker for any illness except syndromes that centre around highly elevated cytokines, such as...

The nanoneedle paper is only suggestive evidence - the samples were not blinded, we don't know what was causing the effect, the study has not been replicated. It's too little evidence to pin any hopes on at this point in time.

"on the way to feeling much better" is spin, meaning she is not yet better, but hopes to get better... :(

Well said. I too don't understand why people anyone would think the two are linked in any meaningful way.

Why then do they believe in the psychological findings that have similar flaws? Small sample sizes, weak effect sizes, poor sensitivity and specificity, (often) lack of correction for multiple outcomes and so on?

I still don't understand why people conclude that fatigue sensation is "protective"? Pain is protective. Fatigue sensation is something else. We know that fatigue sensation is associated with uncertainty about the level of motor units recruited to perform a movement at a specific force. Which is...

She can't answer the question because it would force her to admit she actually agrees with some points of the 'activist' criticism.

Curious. I hope they actually work though and don't just contribute to tablet-dropped-on-face injuries.

There is no elephant in the room, what the hell are you talking about!?!

More nonsense about the sense of fatigue being "protective" in the abstract. The sense of pain is protective, but fatigue is not pain... The brain does work in a predictive/anticipatory manner, but it is a non-sequitur to suggest this is why cognitive behaviour therapies and stress relief...

It sounds more like a cover-up. "Finalising" the review doesn't take two months, unless the dispute has not yet been resolved.

He's suggesting that the 'pacing' arm was an active control group that magically controlled all of the possible biases, despite lack of blinding. He also hypothesises that patients had a more positive view of 'pacing' compared to CBT or GET that would translate into greater bias. Of course we...

They're close minded scientists. Babies have curiosity that these people seem to lack.

That is pretty much the difference as far as I am aware.

As they say, it's who you know, not what you know/do...

Where did these emails come from? I'm glad Tovey is not bending, but I wonder if they authors are expecting his replacement to be a push-over? I agree "minimal important clinical differences" cannot be defined as something so trivial and more importantly, clinical differences need to be...

Hopefully they will grant your request in good faith!

Just don't sign up for the CAKE trial...

https://www.meassociation.org.uk/wp-content/uploads/MEA-Petition-Comments-24.07.17-1.pdf Change.org petition "The NICE guideline for CFS/ME is unfit for purpose and needs a complete revision"

:rolleyes: It's pointless reading too much meaning from tweets like that.