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Yes, this is exactly how I feel too. And then there will be the crosstalk between those who managed to spontaneously recover, giving random advice to those who weren't so lucky.

Does anyone know when this was published? I can't seem to find any reference on the http://telesofia.blogspot.com/ blog or on Giada Da Ros' Twitter (in 2020). The most recent reference was from April 1st, so it has to be after then...

The idea that NSP12/13 could be a cause of CFS is the opinion of the journalist, CFS is not mentioned in the preprint at all. The hypothesis doesn't really explain why symptoms persist for a long time even after the individual has recovered from the viral infection itself.

Given all the money thrown at COVID itself, surely they can spare some money to investigate the role of the autonomic system in such patients? I'm not convinced this is the problem, but it isn't exactly hard to investigate.

I can't conclude much from this. The study overall is reasonably well conducted and written with a variety of visualisations and analyses. But none of the findings tie in well with other studies. The discussion is weaker than the rest of the article, the sections on HPA axis in particular read...

We already suspected much of this from SARS-1 (consequences of ACE-2 being targeted), but I guess some people want to rediscover the wheel. Also, the problem isn't merely clotting, but rather the difficulty the body has in clearing those clots, hence blood thinners aren't necessarily going to...

It's curious that Swedish epidemiologists keep trying to find ways of claiming far more people have been infected than have tested positive.

This study is notable for using a variety of pain threshold tests. I suggest that any studies on Fibromyalgia or CFS or ME should also use this more robust methodology. I also suggest changes in pain thresholds if detected in some patients may suggest something else is going on peripherally or...

Several of the studies did just that (Hodges 2017 and Larson 2019), but I agree more could help. I've tried to keep the following page up-to-date https://me-pedia.org/wiki/Two-day_cardiopulmonary_exercise_test Those with moderate-severe cystic fibrosis are going to have quite different...

The method is interesting, but claims of "cure" are premature, if not dangerous...

They're often considered to be the same thing, but I think this is a mistake. To me, "Anaerobic threshold" is a misnomer since it doesn't specifically reflect what is going on in the muscle fibres. It is also important to note that arterial carbon dioxide pressures remain relatively constant...

Seems more than a little implausible...

Note that some bacteria express their own HSP60, so that may explain the cross-reactivity, rather than autoimmunity itself. HSP60 is an intracellular protein, so isn't normally exposed to the immune system so antibodies directed against human HSP60 would need its own explanation. I haven't read...

The ventilatory threshold is a physiological set point, the fact that it is reached earlier (in terms of power output) on the second day is objective proof of increased fatigue. Control subjects (sedentary controls and MS patients) are able to replicate their performance at the ventilatory...

I don't understand the logic of requiring severe patients to do this, but... Given this is another replication, how long can medical doctors and other scientists deny that this is the most consistent finding to date? It is frustrating that they're not stating the actual max heart rates of...

It was the puppy-eyes that got you, wasn't it!?!

That sounds painful! (sorry if this in inappropriate, but it is funny!) Seriously though, Fink is trying to claim that prolonged pain/injury after motor vehicle collisions is mostly due to psycho-social factors and whiplash-associated-disorder doesn't exist (it's literally crossed out and BDS...

This is a rather alarming and saddening conclusion!

It is notable that they never contest the fundamental methodological issues directly.

Reminds me of the glucose analogy that a certain someone likes to mention occasionally...