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Yes, I think the major problems of selection bias, even with such a large sample, make conclusions about sex differences, and also subsets based on onset type unlikely to hold. There's a typo there, a missing 'are'. I was disappointed to see this. There are many people I would have liked to...

Interesting re recruitment: Again, I think better wording would be "Females with ME/CFS reported more comorbidity diagnoses..." I think it's likely that females with ME/CFS may be more likely than men with ME/CFS to be given diagnoses like depression and fibromyalgia by doctors. Figure 4...

This isn't science, it's mostly advertising. There were subsequent infections. The patient was given all sorts of drugs, which may have helped, but may also have contributed to the symptom load.

The PPI aspects of DecodeME are truly impressive. I'm not entirely sure that all of the information about PPI belongs in this paper, especially given a separate paper largely covers that ground. I'm genuinely not sure, as perhaps the high PPI involvement is such a step forward, it should be...

So many good things about this paper including the inclusion of people with ME/CFS in the writing team (including a number of our members), the open peer review that is underway, and the plain English summary for improved accessibility. Very minor points that maybe are worth mentioning given...

$50 million boost for long COVID research as parliamentary inquiry hands down report ABC article

Crossposted with Sean: The forum thread on the enquiry is here: Australia: 2022 Parliamentary inquiry into Long Covid and repeated covid infections - report issued April 2023

From an email from the Australia Parliament: Report published: Inquiry into long COVID and repeated COVID infections The House of Representatives Standing Committee on Health, Aged Care and Sport has today published the report for its inquiry into long COVID and repeated COVID infections...

Yes, I have to wonder what the Long Covid advocates were thinking when they agreed to the overly broad definitions of Long Covid, e.g. the WHO definition. They might have thought that a broad definition would help make the problem appear bigger and more important, perhaps they didn't want to...

Even if 50% of people with one definition of Long Covid meet ME/CFS diagnostic criteria at 4 or 6 months, it doesn't mean that a lot of those people won't recover. We know from prospective studies of ME/CFS that a lot of people do recover within a year or so of onset.

Here's a taste of the case studies: I find the certainty in the abstract really remarkable. Just maybe acyclovir in the early stages of an infection might reduce ongoing symptoms. But, there's really nothing here to suggest that anything is going on but resolution of symptoms over time...

I hope members will complete the questionnaire. I think that Long Covid is term that should not be defined medically beyond 'covid-19 causes a number of health conditions with impacts after the acute Covid-19 infection has resolved'. I also think that it is more useful to recognise those...

OK, I'll have a go. I can't comment on the credibility of the hypothesis - for me to unpick that would take a lot of time. For what it is worth: My folate levels are unremarkable, not elevated as this team suggest many people with hypermobility are (and I would qualify as 'hyper mobile'). The...

That's the same 14 April Sky news article that TiredSam linked above It gives the appearance of an unedited media release e.g.

A trial protocol for a study of tVNS on post-cancer fatigue: Effect of transcutaneous auricular vagal nerve stimulation on the fatigue syndrome in patients with gastrointestinal cancers — FATIVA: a randomized

Discussion thread on this treatment here: Vagus Nerve Stimulation The tragus (part if the ear) as a place for the stimulation is questionable - when I last looked, it seemed likely that the vagal nerve did not enervate the tragus. The sham treatment in this study protocol seems a bit weak - no...

Is there anything stopping a group of us writing a new review for Cochrane? What would be the steps?

For those of us getting confused by all the 'm's' in front of RNA and DNA: messenger RNA (mRNA) - a single strand of RNA. Gene > transcript of the gene is the mRNA > the mRNA is read by a ribosome to make a protein (transfer RNA (tRNA) bring the Amino acids to make the proteins) microRNA...

I understand that that idea has been resisted due to the desire to have a fairly ethnically consistent sample to cut out unrelated genetic variation. (I still think that sampling places like Australia, New Zealand and Canada wouldn't disrupt that too much - and it would presumably be possible...

From a recent paper specifically looking at people with post-Covid exertion intolerance, a finding of increased numbers of CD169+ macrophages: But, this latest study might indicate that a persisting increase in CD169+ macrophages is a general post-Covid effect. It's great that Maureen Hanson's...