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This paragraph (still in the Introduction) starts by noting another study that contributes to the fact that, despite the problems I noted above, the literature about links between depression and anxiety and CFS and fibromyalgia actually isn't very compelling. That is, the 'most recent...

Just looking at the first paragraph of the introduction, it is hard to imagine how more faulty assumptions could have been packed into it: The author is already on shaky ground. We have seen studies here that suggest that the incidence of depression and anxiety aren't markedly different to the...

Thank you @Hubris, for the validation. I agree with the sources of hope that you have - decodeMe, the NIH studies, Maureen Hanson. I think that any disease community would have performed similarly under the circumstances, and no one deserves this. I have to believe that we can help create a...

which really underlines the problem of the definition of Long Covid, the heterogeneity of it. We need to argue for stratifying, including by PEM-requiring ME/CFS diagnostic criteria.

Proteomics It was tempting to go through the 32 proteins, finding out what each one does. But, I think we would need to have the data run for just the people reporting fatigue, and that's just 7/14 people, so the sample would be very small indeed.

Metabolites FWIW in such a small sample with substantial co-morbidities Upregulated : ornithine, N2-Methylguanine, L-Dopa, Glutaric acid, 3-nitrotyrosine, aspartyl glutamate, Downregulated: Gluconolactone, stearoyl sphingomyelin, phosphorylcholine, N-(gamma-glutamyl)ethanolamine...

The report of osteoporosis and necrosis of the femoral head is, I think, the first I have seen related to bone health in people with ME/CFS. Is anybody else aware of any other reports related to this? The paper notes: So, it sounds as though a treatment regime specific to this group may be...

I was thinking of something more deliberate than that i.e. a mutual observation that the WHO definition is too loose, and the identification of an opportunity to paint Long Covid as having a substantial mass hysteria component.

? SARS-CoV-2 triggers HERV-W and -K ENV mRNA early transcription along with HERV-W ENV protein in peripheral blood mononuclear cells (PBMC) of healthy donors The interesting thing in this section was not so much that exposure of healthy leukocytes to SARS-CoV-2 resulted in transcription of the...

Well yes, in principle of course I agree. And I think that's really true for a treatment. I did think people might disagree with me saying objective outcomes might not be absolutely required in this particular case - but I'm going to try to defend it. The question of whether information about...

A reminder that this webinar is coming up. In the registration process, there is a field to record questions to the researchers. Unfortunately, it only has a character allowance long enough for one sentence. Questions can be sent to kg180@nova.edu. Or, if you prefer to note questions here, I...

A finding of more research needed: HCWs seem to be in favour of multidisciplinary care, as is the recent QFS guideline, although it is noted that there is no evidence to support that approach. There's discussion of patient dissatisfaction with QFS care and acknowledgement that there is no...

Ref #16: Bronner MB, Haagsma JA, Dontje ML, Barmentloo L, Kouwenberg R, OldeLoohuis AGM, et al. Long-term impact of a Q-fever outbreak: An evaluation of health symptoms, health-related quality of life, participation and health care satisfaction after ten years. J Psychosom Res. 2020;139:110258...

I thought this was interesting, in relation to the possibility of a latent pathogen. It could be that some people are reacting to such a latent pathogen (QFS). Whereas others don't react, but the pathogen can reactivate months or years later and cause problems (chronic Q-fever).

Silly, but it happens. Emerge, the Australian ME/CFS patient charity, appointed as their medical advisor a doctor who promotes all sorts of pseudoscience. When I contacted the CEO to explain why this was concerning, I was told that he is very respected and I didn't know what I was talking...

The whole things seems a bit weird and dodgy. Goodness might be hard to define, but it doesn't mean that we shouldn't try. Pursuit of truth is definitely not the only goal; censure and restriction are necessary sometimes. There are lots and lots of experiments that should never be done.

Patients do care about this, this is part of the problem. We all want to feel that we have been listened to, and treated with respect. And that there is something that can be done to help us feel and function better. If a health care provider seems empathetic and promises to provide help...

Good article about supplements and the hype machinery that promotes them. It makes the point about plant supplements that they can vary a lot in active ingredients from season to season and plant to plant. Even remedies that have been used for thousands of years can be problematic, because...

A very similar recent study by Chalder et al of UK young people came to a similar conclusion of 'nothing to see here, move along': (follow the arrow to the thread) Looks like coordinated action to me.

It feels as though there is a campaign by BPS proponents to minimise Long covid, by showing that lots of people who tested negative to Covid report having a symptom. Why it should be news that e.g. headaches or feeling tired are fairly common in the broader population, I really don't know. I...