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Hormonal trends in patients suffering from long COVID symptoms, 2022, Sunada et al There's a related paper from the same Japanese group.

They are suggesting that, in those patients with fatigue, more fatigue equates to higher levels of cortisol. But The cortisol levels didn't differ between those Long Covid patients with (right) and without (left) fatigue. It's hard to compare these levels with healthy people, as the...

Just looking at the inter-quartile ranges, there's a great deal of overlap: ME/CFS: 59 - 354 Fatigue, not ME/CFS: 40 - 252 No fatigue: 38-209 My ferritin levels have been around the 75 ug/L (micrograms per litre). If I google, I get: One microgram/litre (ug/L) equals one nanogram/millilitre...

They seem to have made a good effort to diagnose ME/CFS:

I think we may have commented about this before, but I'm not keen on the Moreau team applying the inflatable cuff as a stressor and then making measurements 90 minutes later and saying that these are measurement of PEM. They might measurements of a stress response, in much the same way that the...

Not sure if you've had a chance to watch the video yet, @Midnattsol, but Maureen sets up her talk very nicely around your point about asymptomatic infections. She cites some research on people who were tested for Covid-19 very regularly. The majority of people actually had an asymptomatic...

IIMEC15 08 Professor Maureen Hanson 15th Invest in ME Research International ME Conference 2023 29 minutes Terrific presentation from Professor Maureen Hanson including some unpublished work I think we are getting close to some real answers - exhausted t-cells, abnormal classical monocytes...

It's not quite zero sense, I can see why they might think that. I suspect many of us thought, when we first weren't bouncing back from an infection like we expected to, that we just needed to ease ourselves into things, and tried to do that. And failed. Often we've tried repeatedly, and often...

(Not on the study itself, but quoting some of the text in the paper) There's no controls for that finding, but it sounds significant. Indeed, if young athletes are developing myocarditis at unusual rates, it raises the question of how protective high levels of exercise are. Did young...

And there's at least one typo - it's not a pre-print. It's not that this study is completely terrible, it's just that the paper doesn't tell us much. There are substudies with smaller numbers of participants, but there's not enough granularity. The response rates raise issues. The...

Same! Hard flooring is definitely the way to go. Of course, childhood asthma gets better over time for a lot of people, including me, so there's that too.

That's Suzanne O'Sullivan. Just because she has written a story, it doesn't make it true. The patronising nature of that story is what sticks out most to me. The consultant is examining a woman who says she is blind, and doesn't tell her that there are nine junior doctors, medical students...

I don't think this was a population sample - for example, people with a history of autoimmune disease were excluded. This was a relatively young sample, median 35.5. years. 51% with a BMI less than 25. 30% with PASC at followup - approx 4 months (31 people with PASC; 73 without). Vaccination...

And a lot of harm when not.

It's an interesting question. Maybe some easier to talk about examples: we fostered some SPCA rescue dogs for a while. Some of them had been traumatised and had problematic behaviour. Maple, the little Jack Russell, cowered under the bed; Frankie, a sweet collie, peed on the bed. They pretty...

It's quite a full-on abstract, in terms of the impacts it is suggesting. The healthy controls weren't allowed to have had a history of Covid-19, so it's harder to say for sure that the brain findings are related to the persisting cognitive issues. I'm also a bit suspicious that the people who...

I think I have been a skeptic for a long time when it comes psychogenic illness. It may possibly be the result of having childhood asthma. My first memory of encountering someone thinking a disease was psychosomatic and me thinking that idea was stupid was when I was sitting in the school sick...

There were also a range of poison gases used in WW1, often in different combinations, along with poor nutrition and other factors. The poisons, which were typically delivered in glass vials in the shells, probably also contributed to temporary and longer term psychiatric symptoms caused by...

I think we can say that they have shown that the virus can and does infect the vagus nerve in severe acute cases - and that's something. It's a shame they weren't clearer about what they found in the five controls who died of other causes, and that they didn't tell us whether those cases had...

Okay, looking at the paper. I've criticised a lot of the vagus nerve related stuff - the clip on the ear that is supposed to send a current to the vagus nerve when there was little evidence of a neural connection; the singing in the shower to tone the vagus nerve; the lack of clarity over...