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I find it rather interesting that there is evidence of brain injury at all - it is seeming to be a consistent finding (although certainly not in all people with a Long Covid label). Some of the levels of GFAP were over 100 pg/ml, so, not insignificant, I think.

Other infections that might cause ME/CFS: e.g. (from an another paper on the same study, linked in post#2 above) Case definitions Then there is the question of who was labelled as having Post COVID-19 Condition: (from that other paper on the same study.) Given that the participants were...

It's as if Wyller did this expressly to squash the idea of Long Covid as a biological issue, and instead to promote the 'there's nothing to see here, it's all in their minds' idea. So the SARS-CoV-2 negative group consisted of young people who 1. had turned up for testing due to a suspicion...

I'm interested in the low levels of IFN-y and high levels of GFAP found in some people with LC. Those analyses do not have the same problems of no individual data and no convalescent controls that the autoantibody studies have. Note that pro-inflammatory cytokines did not differ between the...

Fabulous, @Tapanui 'Flu

I thought people might be interested in this 1998 paper, in the light of the recent studies claiming to transfer Long Covid symptoms to mice via IgG from Long Covid blood. I wonder what came of this research. These researchers did not pool human sera samples.

Transfer of human serum IgG to nonobese diabetic Igμnull mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren’s syndrome - link Christopher P. Robinson,* Jason Brayer,* Shigeo Yamachika,* Thomas R. Esch,† Ammon B. Peck,‡§Carol A. Stewart,§¶...

Certainly MS is different. But I think it's still legitimate for the ME Association, for example, to expect to have credibility when publishing a guidance on operationalising the ME/CFS guideline. To some extent, if patient charities act like respected patient advocates then at least some...

Phosphodiesterase-5 (PDE5) Inhibitors In the Management of Erectile Dysfunction

This forum thread may be of interest: Use of sildenafil (viagra) to alter fatigue, functional status and impaired cerebral blood flow in ... CFS, 2020, Friedman (Pfizer) There were hints of sildenafil helping with CFS symptoms, but problems with the study meant no conclusions could be drawn...

Yes, it's so true that efforts to educate can be completely counter-productive if not done right. (And probably even sometimes when they are done as right as is possible). I do think that the fact that the document has been produced with the support of a number of patient charities, and those...

That's very useful context, thanks @Cinders66. I think though that we do need to worry about what sceptical doctors will think, because that is the audience that I think we are trying to persuade. They, to a very large extent, are the ones with the control when a person with ME/CFS is in...

And so too does CBT for ME/CFS, it has much the same components ('You are not a reliable interpreter of what you are feeling', 'You need to follow my instructions', 'You will only get better if you want to, and you put the work in', 'Your personality is the problem, and we can fix it'.) I...

Here's the link to the website: https://www.cognitivefxusa.com/ They are primarily a post-concussion treatment facility, and the 'develop new neural pathways' approach could make sense I guess. But the fact that the woman in the video above said that she had an fMRI done and it was all red...

For more discussion of the therapy promoted in that video see this thread: Cognitive fx - brain training

Yes, it's essentially an advertisement for cognitive exercise therapy. It shows really well how these behavioural treatments 'work': the desperate desire on the part of the patient to be well again; their appreciation of the therapists who are kind and validating and seem to have the answers...

It depends how much diagnostic effort is made. I think the evidence we have, from the NIH study (despite them having been carefully diagnosed by experienced ME/CFS clinicians, at least 3 out of 20 I think), the fact that some members here have gone on to be diagnosed with other things (at least...

Yes, I think, although I am not sure, that, regardless of whether someone has been recognised as having POTS or blood pressure issues related to standing, nearly all of the people in the sample would recognise symptoms related to orthostatic intolerance. For example, they would not like...

for P300 latency and amplitude: That's interesting.

For beta rhythms: It is hard to understand exactly what they are measuring: They seem to be talking about the power of the signal I'm not at all sure that a low powered beta rhythm is a bad thing. See for example this study on beta rhythms in language: “Too Many betas do not Spoil...