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I've talked about low pulse pressure in ME/CFS before. I think it is a clue. That said, I don't want to detract from the need to get the symptoms you mention checked out with your GP.

More on that, the rabbit study above reported the endothelin-1 synthesis is decreased by alcohol. About endothelin-1: There is a bit of evidence that endothelin-1 is increased in ME/CFS e.g. in two studies by different teams: What if over-production of endothelin-1 in ME/CFS was an...

I wouldn't be surprised if there was an effect on vasodilation, compounding the effects of sitting upright for the length of time it takes to drink and socialise. So, blood goes to the feet, not the brain. And that can make us feel a bit ill, quite rapidly, as well as perhaps triggering PEM...

Another great article from @Naomi10, discussed on the Miranda Hart thread:

Thanks, fixed.

Electron microscopy of mitochondria So: small numbers of samples, controls not well matched (very different ages, and the controls aren't healthy controls, post-Covid symptoms of the Long Covid group are primarily olfactory problems, so not very relevant to ME/CFS Unfortunately, I think all...

A team from Hungary: Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Their hypothesis: They looked at: nasal and bronchial samples - mitochondria visualised with transmission electron microscopy levels of proteins crucial to mitochondrial...

Biological research paper out from a team based in Szeged, Hungary: Novel biomarkers of mitochondrial dysfunction in Long COVID patients, 2024, Szögi et al.

Dr Systrom wants to understand PEM - Analysing blood biomarkers and muscle biopsies may shed some light on the pathophysiology. 3.00 talks about his invasive CPETs at the Brigham, has been doing these for about 7 years in ME/CFS: Vascular abnormalities found in both ME/CFS and LC -...

So, given the above, if we convert Jarred Younger's CRP ranges to mg/L: <3 mg/L is healthy; 3-10 mg/L indicates mild inflammation; 10-30 mg/L indicates moderate inflammation and >30 mg/L indicates severe inflammation. That seems to be in line with the population data and the evidence on...

From what I can see, Labcorp's levels have a reference 4: Pearson TA, Mensah GA, Alexander RW et al. Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals from the Centers for Disease Control and...

I have found the literature on CRP levels confusing and contradictory. For what it is worth, my CRP levels, in mg/L, had a reported normal range of <5mg/L. Since illness onset, my levels have been from 6 to 20, and usually 10 or more. My GP remains completely unimpressed by a level of, for...

Comments on the Younger video: I like that he uses the name ME/CFS. 74 women with ME/CFS and 31 female healthy controls 2.35 mins - chart of CRP results. He's using mg/dL. He says: below 0.3 mg/dL healthy; 0.3-1.0 mild inflammation; 1.0-3.0 moderate inflammation; >3.0 severe inflammation (so...

They are doing that already. Acupuncture is recommended in the NICE Chronic pain guideline.

Yes, exactly right. This paper found that the treatment they have to beat is CBT. And yes, if the same sort of research methodology is used, pretty much any treatment that can be made to seem a bit credible (e.g. thousands of years of medical traditions) can be at least as good as CBT.

I guess a psychosomatic expert might suggest that the meme of Long Covid isn't perfectly replicated in different countries; culture influences the expression of somaticism. Whereas it looks as if there are problems with the collection and recording of data, as illustrated by the quote @SNT...

:D Probably also no records of "cognitive dysfuncsion".

We have a thread for the published paper here: The Concept of ME/CFS, 2024, Edwards

Author is member @Jonathan Edwards Forum discussion undertaken as part of the drafting process is here: The Concept of ME/CFS

https://www.qeios.com/read/NXCXM1 Qeios Abstract The concept of ME/CFS (notionally standing for myalgic encephalomyelitis/chronic fatigue syndrome) has evolved over the last twenty years. This review compares it with the historical terms chronic fatigue syndrome, myalgic encephalomyelitis, and...