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Haunting innate immune memories of COVID-19 In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to, for example, post-acute sequelae of COVID-19 (PASC). In this issue of Cell, Cheong et al. show that severe infections...

Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization Abstract Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the...

SARS-CoV-2 RNA Persists in the Central Nervous System of Non-Human Primates Despite Clinical Recovery Abstract Adverse neurological and psychiatric outcomes, collectively termed the post-acute sequelae of SARS-CoV-2 infection (PASC), persist in adults clinically recovered from COVID-19...

“Therefore, each subject to be diagnosed with ME/CFS must undergo a Fukuda criteria evaluation and procedure that each unit has established using batteries of validated self-administered questionnaires. “ “Patients were eligible to participate if they were 18 years, had a confirmed diagnosis of...

I remember when I went from full time working and high level athlete to fully bedbound within one night. I guess I just shouldn't have deconditioned so hard in that one night.

Dissecting human population variation in single-cell responses to SARS-CoV-2 Abstract Humans display substantial interindividual clinical variability after SARS-CoV-2 infection1,2,3, the genetic and immunological basis of which has begun to be deciphered4. However, the extent and drivers of...

The Netherlands seems to be the Wild West in terms of naming conventions. The BPS group calls it CVS and uses psychological criteria to diagnose it and then manipulates ME/CFS studies with that, they couldn't care less about guidelines. Then there's a misguided adovacy group that believes that...

Results contradict the previous study https://doi.org/10.1001/jamainternmed.2023.0743 discussed here https://www.s4me.info/threads/association-of-treatment-with-nirmatrelvir-and-the-risk-of-post–covid-19-condition-2023-yan-xie-phd-et-al.32483/#post-466630. However, the sample size is extremely...

Nirmatrelvir/ritonavir and risk of long COVID symptoms: A retrospective cohort study We conducted a retrospective cohort study to assess whether treatment with nirmatrelvir/ritonavir was associated with a reduced risk of long COVID. We enrolled 500 adults with confirmed SARS-CoV-2 who were...

Reactivated endogenous retroviruses promote protein aggregate spreading Abstract Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates...

Haven't read anything of the study apart from the first word, which has been misspelled.

A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model HIGHLIGTS Imaging flow cytometry utilizing a novel rapid flow cytometric detection method is a promising method for detecting amyloid fibrin(ogen) microclots in conditions associated with...

Agreed. I wanted to mention that all these patients seem to still be fit enough to partially work (at least that was the case for IDO2 study), were at least fit enough for hospital appointments 3 days in a row along with a bicycle test and have had Long-Covid for less than 1.5 years, so...

Haven't read the paper yet, but Scheibenbogen recently said in an interview that PEM has to have a minimum duration of 24 hours for her to consider it to be the type of PEM experienced in ME/CFS.

Muscle Abnormalities Contribute to Post-Exertional Malaise in Long COVID A poster presentation of the very soon to be published work by Rob Wüsts team has been uploaded to Twitter. Paper now published, see post #8

Long COVID treated successfully with antivirals in a rituximab-treated follicular lymphoma patient with persistent negative-antibodies to SARS-CoV2 Highlights Persistence of SARS-CoV-2 infection among immunocompromised patients are due to inability of the immune system to eliminate the virus...

I've thought about this in the past as well when I first saw this trend in cycling. I know that some users on Twitter have tried it out and even used the same brands commonly used or at least advertised in cycling. Whilst the research is certainly still extremely early and only one study has...

Editorial on the paper The Persistence of SARS-CoV-2 and Its Role in Long Covid Postacute sequelae of coronavirus disease 2019 (PASC), more commonly known as long Covid, manifests as ongoing symptoms in various organs of the body more than 4 weeks after the resolution of acute Covid-19.1 A...

Really awesome to see this work, especially from researchers I wasn't even aware of, with funding from the Dutch government. Can someone enlighten me whether their PEM screening is a standard screening method or similar to that used in ME/CFS research? 48.1% respectively 41.2% seems an awfully...

Haven't read the paper yet, but the question will be whether their analysis was intricate enough to have studied the results presented in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272838/ and https://www.frontiersin.org/articles/10.3389/fimmu.2023.1221961/full.