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It's late and I'm not sure I can follow, but I would have thought that having more symptoms (number of CDC symptoms) would be associated with worse prognosis because it reflects illness severity. Other than that these results seem to be in line with an etiology that is not related to...

Underdiagnosis in general is a huge problem. We don't discuss it that much because most of us are diagnosed but estimates are that for every diagnosed person there are up to 9 that are undiagnosed. While there isn't any real treatment, a diagnosis would allow these undiagnosed patients to...

This idea is well supported by a large study by Jason et al. It's 20 years old by now but it seems reasonable to assume that this problem hasn't gone away.

Norway is doing a lot of work here relative to its size.

Maybe a legal expert should speak to the NICE panel about the implications?

Jason et al did a big random sample prevalence study and found that CFS affected all ethnic and socioeconomic groups. At the time it was widely believed that CFS was an illness of the white middle class. In reality the non white middle class patients were just not being diagnosed with it.

@Jonathan Edwards how much evidence is needed to make a good argument that GET is or may be harmful? Based on what I know the paper by Karl Morten will show that after a course of GET, metabolites associated with energy production decline. The last time they spoke about this there was no...

What is linkage disequilibrium? If I understand it right, it's saying that linkage disequilibrium is when variants of different genes tend to occur together more or less often than by chance.

Is it hypocrisy or a compulsion to position oneself in debates with outrageous, unexpected, unintuitive, offensive ideas? Like claiming that patients with CFS are sick because they act and think like a sick person.

Maybe it doesn't make sense because we're trying to understand it from either the "autoimmune" or the "infection" angle but it is neither of those, but something else that nobody has really considered. Every known disease mechanism was once unknown. That researchers are having so much difficulty...

I don't know him and don't want to vote for someone I don't know. For all I know he could be a secret LP enthusiast.

I read the comment about Bristol and immediately thought of Crawley and co submitting comments to NIH. That is scary. Although Bristol group could also refer to a patient organization. Either way it's good to keep pointing out that CBT/GET are based on science that wouldn't be accepted if it was...

Scary. I immediately submitted some comments about CBT/GET and low standards of evidence holding back scientific progress.

$5000 is 5.26%. So we're still going to be about 19% short of the goal.

It seems to say nothing that's unexpected or inconsistent with a purely organic cause of CFS. eg. those in the mild fatigue category are more likely to also be in that category at follow-up. In other words, those who are mildly fatigued are mildly fatigued. Those with shorter illness duration...

Sharpe should continue tweeting about the lightning process. :D It makes him look like a raving quack. I think it also reveals how he really sees CFS: as choice and all in the mind.

Nice work.

Looks like we won't make it unless some wealthy donors have held back to see how much will be needed.

One would think that millions of years of evolution failing to eradicate "negative thoughts" is clear evidence that they are not a flaw. Negativity is really important. Without it, you risk becoming like these positive psychologists that are so full of positivity they just can't stop believing...

Sounds a bit like the lightning process. With bleach of course.