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From the front page of the website: And The real question is there going to be some sort of transition plan for current patients?

Yes, it is clear they are ignorant about the reality for most patients. CFS is not merely post-viral-fatigue...

Edwards' statement is not consistent with current understanding of effort perception and is inconsistent with the relationship between effort perception and performance at the ventilatory thresholds in more recent 2 day CPET studies... The equivocal association of deconditioning and performance...

Mostly unrelated to the study. This is one of the key reasons why control groups are used... Politely, I'd say the difference in reported adverse effects is certainly in part due to methodological differences.

Most data actually shows fewer autoimmune adverse events for young childhood vaccines versus adults, so it may actually be beneficial to give at younger age vs older age. The same goes for combination vaccines - less actual injections lower the risk. People who suggest that the combination...

"Continuous stress-loading" in rats is not a model of CFS and never will be.

Recruit all your friends! LOL

I think that is the most likely scenario - selection bias... Chronic fatigue is a common long term consequence of certain autoimmune diseases, even once the primary symptoms are attenuated/improve.

A bit of Google Scholar sleuthing suggests it was the CDC who started using the term AFM in 2014.

POTS is about blood flow based on body orientation. When climbing stairs, the body is not really changing in orientation besides maybe a bit of lean. It is the legs that are doing all the work moving the body against gravity, hence the major difference is simply the metabolic demands of the...

Again, please explain how?

Apart from the initial standing process, how exactly?

The main issue with inclines is simply that it takes substantially more power to climb than walking on a flat plane. Otherwise there is nothing particularly special. A graded CPET on a treadmill can simulate specific gradients by requiring a specific amount of power.

I haven't looked into it in any depth, he believes exercise intolerance in POTS patients is due to pre-load failure. But I don't see why the central veins would fail to constrict with the peripheral veins also failing to dilate at the same time?

Is this the problem though? Dilation of arteries leads to reduced blood pressure and heart rate due to increased blood flow. Note that the post exercise hypotension noted in healthy people is likely associated with prolonged dilation of arteries (1-2 days) and proportionally more blood being...

The problem isn't frequentist hypothesis testing, the problem is people inappropriately assuming that because a finding reached a pre-defined alpha, that it is automatically true.

I have great confidence in your conclusion. ;)

If they truly have chonotropic incompetence, there is no "forcing", the patients will simply need to stop early. What is interesting is that in young healthy people, deconditioning can actually result in slightly higher than normal heart rates at VO2Max than trained participants. The idea is...

Yes. They have dropped the ball for a long time. ME is a special case and it is in their scope to focus on building research capacity, which means funding more specialist centres (which will lead to more pilot studies and in turn more NIH applications). Most scientists don't want to build a...

The purpose of this study is to discover/further characterise rare genetic diseases...