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I'll comment again in more depth when I've read the full paper, but I think this paper is barking up the wrong tree for most patients (there are other reasons for the lower HR peak). But it is equally disappointing that researchers have been mentioned chronotropic incompetence for years, but no...

The problem is there is some evidence that fatty acid transport is also disturbed, meaning a ketogenic diet on its own may actually make things worse.. . https://www.ncbi.nlm.nih.gov/pubmed/21205027

Not the first time I've heard of a paper to be sent out for peer review, gotten good reviews and then be rejected by the editor. You have to wonder why the editors want to waste everyone's time...

The proportion of 1400 down to 69 also suggests participation biases, rather than merely filtration due to criteria... No, but, well, they're probably both true...

If they're not doing a "full update" (meaning they're not examining new studies), why does it take 6 months just to make a few modest changes!?!

It sounds much cleverer to say "putative", rather than 'shit we just made up'.

Lack of scientific specificity is somehow now a virtue. "interconnectedness"

Whereas in CFS there isn't enough evidence from adequate trials, yet patients are told it will help anyway...

If someone spends 3+ months of hope, time, effort and money on some sort of involved therapy and it doesn't work, while this might not be considered a serious adverse effect, they have still been harmed.

Not necessarily, GET is a type of CBT and does not have to be based on reversing deconditioning, but simply to alter beliefs about activity and exercise (eg expectations of symptoms from doing exercise). Whether this is successful is a different question

Me too, seems like strange questions.

But dogs can shows signs of being depressed!?! https://www.petmd.com/dog/behavior/can-dogs-get-depressed

I don't think it is unreasonable to test ACT in a randomised trial, only we need objective measures of improved functioning as the primary outcome and to not conclude that it is beneficial simply because patients answered some subjective questionnaires slightly more positively after the therapy...

That paper along with this recent paper explicitly show the problem is not within the mitochondria. That is a key part of the mystery.

The paper discusses the rational for a short 3-4 hour training session and some of the communicated responses, however doesn't really discuss in much detail about the specific content of the training such that someone else could replicate it...

That's the Nobel prize winning question, but the authors specifically mention this paper: https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-8-93 Which along with the other 2 day cpet papers and related findings in exercise physiology provide clues, at least in my...

Another finding that didn't replicate...

Oh sorry, my mistake.

The notable part about all this is well, short walks don't lead to improved fitness. Either short intense activity (to build VO2max), or prolonged exercise just below the ventilatory threshold (to increase endurance) is required for improved fitness. If you are reporting substantial benefits in...

The parental associations are likely due to participation biases, namely demanding parents are more likely to have children participating in such studies because they want answers. The noteworthy part is the bias applies to the parents, compared to biases of patient participation and response as...