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This "thirds" idea crops up again and again in medicine for a wide variety of conditions. It is a common myth that is never supported by evidence. I think doctors like to believe myths like this as the truth is more gloomy. The thirds claim also makes no sense as there has to be a specific time...

Mind if I ask which country you are from? The GET in Australia/America might be more pacing oriented than that of the UK/Netherlands. One of the key Australian "GET" studies explicitly used the word "pacing" to describe their programme. (which was a fact not noted in the Cochrane review, so...

The elevated HR post exercise is not substantial enough to discriminate between patients and the various other groups you mentioned. A meta analysis of the various HR findings is likely to be published this year...

The claims made are still quite different - the researchers aren't claiming that CBT leads to recovery for these conditions.

Yes. The exception, rather than the norm...

It doesn't. People with other chronically fatiguing syndromes such as post-polio, GBS, Lupus etc also suffer PEM like symptoms. There is one objective sign that cannot be faked, namely a reduction in ventilatory threshold on the 2 day maximum exercise test (CPET), the problem is this test isn't...

The most notable part of this is this bias is still common amongst scientists today.

Rewarding 100% attendance means that people come into work/school when they are ill with infectious illnesses, spreading those illnesses to others. Why is this deemed praiseworthy behaviour, when say, antivaxxers are shunned? Both lead to the spread of infectious disease.

I'm sure Wessely is a "very stable genius".

Wildly optimistic, but that's what we've come to expect from Silicon Valley boffins right?

When you are looking at common symptoms, not underlying causes, the heterogeneity does not matter so much. Lots of researchers have wondered about cytokines as a marker for fatigue in healthy people (or athletes), to no avail. I am confident in saying none of the cytokines are markers for any...

Then, as now, we will not "acknowledge good intentions" while these researchers continue to fail to make any attempt to build trust with the patient community.

I spent a lot of time researching this a few years ago and came to the conclusion that none of the cytokines can be biomarkers for fatigue in patients or athletes. The presence (or lack of) and kinetics do not match at all. I also spent some time looking at the various cytokine receptors and...

Henrik Vogt sounds just like the usual "alternative medicine" quacks...

Measuring miRNAs is not the same as measuring SNPs, but I'd also caution that their miRNA research is subject to the same sort of statistical false positive risk.

There is a worldview difference between us and these people. The "illness" is that we're complaining about are considered to be the symptoms themselves (hence the name "CFS"). Whatever the cause of those symptoms is no matter to these people (psychiatrists and their friends) if we stop...

It sounds like classic narcissism to me - it's more about how she feels and the voices of the patient community are unimportant.

Medicine has always been guesswork. It is more science-influenced than it has been in the past, but we are still quite far from comprehensive science-based-medicine. I'd say the ICC and CCC are quite specific "positive" diagnoses, but NICE and Oxford are still quite nonspecific.

I think she is genuine, but she is rather gullible and doesn't make a very good scientist. Science is not about trying to confirm your preexisting beliefs, but that is all she seems to be doing with her poor quality study designs...

I'm sure it'd be ugly...