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Full title: Butyrate reduces adherent-invasive E. coli-evoked disruption of epithelial mitochondrial morphology and barrier function: involvement of free fatty acid receptor 3 Gut bacteria provide benefits to the host and have been implicated in inflammatory bowel disease (IBD), where...

Now published. The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the...

That was great, thanks Dave. And what stood out for me was that Ed so clearly understands, and explains, that PEM is so much more than fatigue.

Now published. Comparison of T-cell receptor diversity of people with myalgic encephalomyelitis versus controls Abstract Objective Myalgic Encephalomyelitis (ME; sometimes referred to as Chronic Fatigue Syndrome) is a chronic disease without laboratory test, detailed aetiological...

Thanks. I didn't go poking around in the tables so missed that. Labelled like that doesn't really give me confidence in whether or not those 8 people had ME/CFS or not.

"Professor Steve Griffin, of Leeds University, said the study suggests “the approach to treating conditions such as long Covid, ME and CFS [myalgic encephalomyelitis and chronic fatigue syndrome] using graded exercise regimens is entirely flawed. Moreover, it appears that over-exercising under...

Merged thread Guardian article: People with long Covid should avoid intense exercise, say researchers Study finds biological changes may explain why those with lasting symptoms feel muscle pain and fatigue for weeks after working out...

No mention in that paper of ME/CFS.

Neither do I, but you asked what the evidence in this case was, and I highlighted what the authors here claim is the evidence.

"FND was diagnosed in the presence of (i) one or more patterns of deficits consistent predominantly with dysfunction of the nervous system and (ii) variability in performance within and between tasks [6], whereas medical unexplained symptoms (MUS) were diagnosed according to current criteria...

Now open access, https://journals.sagepub.com/doi/10.1177/0011000019888874

Abstract Background and purpose The purpose of this study was to evaluate the possible correlation between SARS-CoV-2 vaccines and the onset of neurological syndromes. The aim was to challenge the association between SARS-CoV-2 vaccinations and the onset of acute functional neurological...

Abstract: The microbes present in the human gastrointestinal tract are regularly linked to human health and disease outcomes. Thanks to technological and methodological advances in recent years, metagenomic sequencing data, and computational methods designed to analyze metagenomic data, have...

Trial By Error: Update on NICE Response to “Anomalies” Paper; Higher ME/CFS Population Estimates in CDC Survey "Last month, the CDC released new estimates for the number of people in the US with ME/CFS. The figure—3.3 million, or 1.3% percent—raised eyebrows and made headlines. Previous...

Trial By Error: Update on NICE Response to “Anomalies” Paper; Higher ME/CFS Population Estimates in CDC Survey "While it was known that NICE had submitted a response, details have generally been lacking. I recently learned that NICE submitted a response on October 1st, which was peer-reviewed...

There is no way that I will use my precious energy and time on completing such a questionnaire. Just maybe there is the chance that this is intended to look at how pwME, due to their reduced energy levels, might adopt behaviours that compared to the average, healthy, norm are then considered...

Obviously some of us here on the forum question how accurately these questions from the DSQ actually represent PEM. "2.5.1 Post-exertional malaise In the DSQ-PEM, respondents rated five items over the previous 6 months on frequency (never, sometimes, about half the time, most of the time...

"Additionally, the questionnaire included the validated DePaul Symptom Questionnaire Post-Exertional Malaise (DSQ-PEM) (22) and four items from the DePaul Symptom Questionnaire-2 (DSQ-2) regarding OI (23, 24), and experienced symptoms (44 pre-listed) with severity scores (range 1–10)." So a...

Now published. Background: Exercise-based treatments can worsen/exacerbate symptoms in people who were SARS-CoV-2 positive and living with post-COVID-19 condition (PL-PCC) and who have post-exertional malaise (PEM) or orthostatic intolerance (OI). Nevertheless, PEM and OI are not routinely...