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Abstract High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge the gap between the genome and diseases. Here we performed association studies of Olink Explore 3072 data generated by the UK Biobank...

Abstract Integrating human genomics and proteomics can help elucidate disease mechanisms, identify clinical biomarkers and discover drug targets1,2,3,4. Because previous proteogenomic studies have focused on common variation via genome-wide association studies, the contribution of rare variants...

The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a detailed summary of this initiative, including technical and biological validations, insights into proteomic disease...

MEAction UK's response, https://www.meaction.net/2023/10/03/meaction-uks-response-to-dhsc-my-full-reality-the-interim-delivery-plan-on-me-cfs/

8,225 signatures at time of posting. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

Ongoing project: Exploring patterns of antibodies in moderate and severe ME/CFS "One possible route to the development of such a tool is to look at the pattern of antibodies produced by the body as part of the immune response, and the central idea behind Dr Lacerda and Prof. Cambridge’s study...

We obviously have all the responses from our participants to our primary questionnaire, and there will be a secondary questionnaire that will explore additional areas of interest, but we have never called our cohort a registry. There is also The Netherlands ME/CFS Cohort and Biobank (NMCB)...

Long Covid SOS, one of the Long Covid charities represented at the UK Covid Inquiry, posted on Twitter. "Today we found out that @BorisJohnson scrawled 'BOLLOCKS’ across a @DHSCgovuk document about #LongCovid He admitted in his witness statement that he didn’t believe #LongCovid ‘truly existed’...

8,199 signatures at time of posting. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

8,149 signatures at time of posting. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

"Antibiotic use can increase chances of MCAS flares. MCAS flares can also lead to polyreactivity and loss of oral tolerance. Planning for negative side-effects is an key part of the @remissionbiome safety plan." https://x.com/chydorina/status/1708585382013792320?s=20 First do no harm, unless...

Published papers thread for w/c 25th Sept. Facebook: https://www.facebook.com/sci4me/posts/pfbid02c5vVD3SM84LHEi7CnLrSNSHLF7kmtW9VRJ164N5bLEDzUBRVmm3v6c1WEb9BbKLUl Mastodon: https://med-mastodon.com/@s4me/111164552103999065

First Clare Francis Research fellowship awarded "Audrey’s research project will try to identify and characterise factors in the blood of patients that may be responsible for disturbing their mitochondria. Equally important, if Audrey can show that such a factor exists, this could provide a...

"While estimates of how many people have ME/CFS vary, it is thought that around 0.4-1% of the population is affected. This means that up to 250,000 Australians have the condition." https://www.emerge.org.au/what-is-mecfs/ Up to 1%??? Do we know that Australians are particularly likely to...

In sheep. BACKGROUND: The phrase complete vagal withdrawal is often used when discussing autonomic control of the heart during exercise. However, more recent studies have challenged this assumption. We hypothesized that cardiac vagal activity increases during exercise and maintains cardiac...

8,108 signatures at time of posting. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

No, we don't have such a thread. If I started one I think I would be inclined to put it here, https://www.s4me.info/forums/psychosomatic-news-me-cfs-and-long-covid.27/

There seems to be yet another themed edition of a journal centered around FND. Rather than flood the forum with them, the table of contents can be found here, https://www.sciencedirect.com/journal/neurologic-clinics/vol/41/issue/4 where you can find the following delights: Lessons from a...

Abstract The idea that a neurologist would do an 'FND clinic' or that functional neurological disorder (FND) could be a subspecialty of neurology would have been outlandish even 20 years ago but has become a reality in many places around the world. In this personal review, I reflect on 25 years...

Abstract Functional movement disorder (FMD) is a common, potentially reversible source of disability in neurology. Over the last two decades, there have been major advances in our understanding of the clinical picture, diagnosis, and management of this condition. Motor presentation is...