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I think I understand the nuance but not sure. Can you clarify for me please.

One thing I note here as I read though, is an assumption that seems common in clinical trials. This excerpt I fully understand ... [my bold] [my bold] Why is it always presumed that any difference will be positive, i.e beneficial? To me this is has massive potential for bias, if negative...

Huh?! Recovery can only be full attendance surely, subject to normal absences?! One day a week increasing to 1.25 days a week would be only marginal improvement, let alone recovery. It's real cart-before-the-horse toy science. We want to be able to claim recovery; what findings have we got; in...

I've not read / digested all of this thread, but that is an important concept throughout much of life, and particularly in engineering. There is a distinction between accuracy versus repeatability. An instrument may be decidedly inaccurate, but highly repeatable. A good instrument needs good...

Either way, I would think safety testing has to be done for pwME at varying severity levels. One of the major blind spots in much of the BSP-led ME science is the presumption that extrapolation of findings (across severity levels, across diagnostic definitions, etc) is OK. Even if the underlying...

Excellent! :)

I wonder if Dr. Nina Muirhead would be interested in this, if anyone knows how to contact her.

When they first did that it came across as underhanded lip service, so they could just claim to have done something, and their inaction since shows that to be true I think.

Not read it all, but like this bit ...

Link is broken.

Which of course means the key argument that we should be pushing (and I know @dave30th does) is: How can any kind of ethical approval ever be given to a childrens' treatment for which the details are concealed? It's absurd, and one of the most blatant and flagrant violations of children's and...

Yes, that was it. I was trying to get to how solid the information is for this, beyond just hearsay. The more solid the knowledge that children are asked to keep secret their treatment details, the stronger the case would be for child protection violations. But it would be harder to instigate...

The key part of that being "she didn't see". What on earth do you have to do to make people see? As the saying goes: there are none so blind as those who don't want to see. ETA: I do wonder if it highlights a genuine lack of insight and lack of comprehension on the part of some of these folk...

Do you know (and if so are you free to say) how Christine acquired the information behind her comment? Was it from children / parents / teachers she was personally in contact with?

MS: "This is a robust study because patient were allocated to one of the two treatments at random ensuring that any difference seen in outcome between these treatments, is not due to pre-existing differences in the patients." So that's all that mattered then? MS: "The main limitation is that...

Such a person as Ron Davis, having high integrity and very impressive scientific credentials, is vastly more qualified that those who lack either.

[My bold] My highlighted text is a huge clue why the review's conclusion is so flawed.

https://vadamagazine.com/lifestyle/health/esther-crawley-claims-harassment-university-no-record (I think Adam is a member here) ... https://www.coyneoftherealm.com/2017/09/27/parents-should-have-been-warned-about-unprofessional-providers-in-esther-crawleys-smile-trial/ ... Same quote from...

But the more likely it were done once outcomes were predictable, the more damning it is. And I believe the fact they cite the changes were agreed before any formal analysis was done, is a 100% feint. The study design meant they had bags of information to hand, accumulated throughout the trial...

And during a fully UNblinded trial what are the chances (I mean, really!) of the research team NOT discussing how things are going. I just cannot imagine they would not discuss some of this stuff informally. And I most certainly do not believe that the investigators would have had anything like...