Search results

Yes.

"For each experiment, 50 μL of the prepared sample (SI Appendix) was injected into the microfluidic wells" ... I interpreted that to mean a total of 50μL into all the wells, not into each individual one.

Given that the impedance will vary with frequency I wonder if Ron Davis' team have considered looking at the impedance characteristics in an additional way. They have homed in on doing impedance-against-time graphs at 15kHz, but will doubtless have experimented at other frequencies also. Feels...

So it's actually well progressed from square one, pulling the plug as it does on their primary excuse. I rather think they respect @JohnTheJack's extremely cogent submissions :).

Absolutely. I think of my wife as mild/moderate, and no way is she deconditioned. When she is able (which is quite often) she gets on with quite a lot, pacing herself as she does. But then, at various times during the day, has to "collapse in a heap", in a way she never used to have to do, and...

My wife has mild/moderate ME, and has learned to pace herself well. Although she does nap in the day she tries to avoid doing so too near to bedtime, because her nighttime sleep can be quite fitful. But how that would apply to someone with severe MS I don't know.

Yes, I understand and appreciate that. My concern is that until the cellular stress differences can be proven due to something other than deconditioning, then team PACE can still just say they have never disagreed there is something physically wrong with pwME - just that they believe it is...

Looking at the Discussion section, I find it encouraging that Ron and his team have some good insights (albeit not yet proven) into what the biological mechanisms might be for the impedance differences - I don't understand the biology. At this stage there is obviously a lot of ifs and maybes...

Interesting how the ME/CFS characteristic seems to be a greatly exaggerated version of the controls. From time zero the impedance drops initially, then steadily rises again. For ME/CFS, the drop is much more dramatic and for longer, before then rising far more significantly. Also presumably...

I'll bet MS and Co. are over the moon.

Yes. Because it is not sufficient to prove that pwME are not healthy ... the deconditioning lobby fully acknowledge they are not healthy. The crux of it is to prove pwME are not healthy and that any deconditioning is not the primary component of that poor health. Severe pwME are going to be...

As stand alone comments I think they were. But of course none of his comments are ever really stand alone. e.g. Yes, he is right to say that the test results could be due to either the cause or consequence of whatever ME/CFS turns out to be, and that it is important we know. Well yes ... and no...

In these situations the normal way is to home in on a scapegoat or two, who they can blame everything on and takes the flak so no one else gets seriously hit by it. Damage limitation. Ideally all culpable would be made liable. But if they really do manage to put it all on one person, then EC...

I think Bristol's silence says it all. They are profoundly aware I think, they have no answer that won't drop them into a huge dog pile, so they do they only thing they can think of doing ... dig in and stonewall. Ideally it needs some higher authority to force them out of that foxhole, compel...

So if these results are reflecting an underlying cause, then that would tentatively suggest all the patients are in a common grouping, rather than distinctly different sub-groups. But of course the results could conceivably be reflecting similar effects from different causes. Would be...

SW said: "is it measuring the cause, and not the consequence, of illness?" If it really proved to be a unique biomarker, would SW's comment matter?

Yes, this sentence, "The test, which is still in a pilot phase, is based on how a person's immune cells respond to stress" is going to be widely misinterpreted as psychological stress, rather than biological stress.

Ditto :thumbup:

How can it be everything if it is low fat?!

I think it's a bit longer than that. 11:59 PM PDT on 30 Apr will be 07:59 AM BST on 1 May in the UK. So I think there is still a bit over 2 days to go (it's 9:20 PM 28 Apr in the UK at the moment).: