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I feel more positive. I was watching an Australian tv program, a light comedy thriller drama sort of thing, the other day. One of the main characters, and one of the heroes, is a young woman with endometriosis, who initially had been fobbed off and disbelieved, but who was eventually believed...

There did seem to be a lot of pushback on the NICE Chronic primary pain guideline, including from clinicians. Is there any way that we could combine forces with those interested in getting that guideline reviewed? For those with connections in NICE, do you get the feeling that there would be...

I checked out that reference, my commentary is on that linked thread. It most definitely is not evidence for an altered HPA axis. Not even remotely. Unequivocably, not. I won't say what I want to say about these authors. But if researchers don't take the time to actually read and think...

Really the only notable biochemical findings are for norepinephrine and epinephrine (also known as adrenalin). First some background: Plasma norepinephrine pmol/L - Normal range 414 to 10,049 pmol/L Patients 2067 Standard deviation 835 - so entirely normal Controls 1530 Standard deviation...

Cortisol - my favourite measure Plasma cortisol mol/L Patients Mean 334 Standard deviation 151 Controls Mean 349 Standard deviation 202 Look at the difference between the means, relative to the standard deviations for the samples. There is no difference, nothing at all to suggest that...

Yes, it's like they don't want to say 'there is no effective treatment'. 'poorly responsive to several allopathic and alternative therapies' Allopathic medicine is So, they are saying the symptoms are poorly responsive to several conventional drugs and alternative therapies. It's such an odd...

That final author is the BPS Wyller. (crosspost) Note the definition of CFS - 3 months of unexplained fatigue of new onset. The paper notes that previous attempts at relating gene expression to clinical symptoms of CFS have struggled, and that it might be because things are rather...

https://pubmed.ncbi.nlm.nih.gov/28494812/ Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B cell differentiation and survival Chinh Bkrong Nguyen 1 2, Lene Alsøe 3, Jessica M Lindvall 4, Dag Sulheim 5, Even Fagermoen 6...

(Thread created at the request of a member) IQWIG The independent Institute for Quality and Efficiency in Health Care (Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen, IQWiG) examines the benefits and harms of medical interventions for patients...

It's not the worst review I've seen, but you know that's a very low bar. Sorry, but this is disappointing, it seems superficial. It doesn't change my view of Bansal as teetering on the edge of BPS thinking. What is that actually saying? That immune dysfunction might be involved, but it might...

This reinforces the need for epidemiological studies of the prevalence of ME/CFS and Long Covid in some of the parts the world that are so often left out of medical research (and not just in less wealthy countries - we know nothing about the incidence of ME/CFS in Australian indigenous people)...

This is important. There is IACFSME - I can't see them organising an international response, but can anyone in that organisation say what approach they will take to respond to this? Lily Chu @hope123, Keith Geraghty? There is the IAfME or whatever acronym they are using. There was a brief...

I have a bit of sympathy with that point too. I think the NICE Guideline made energy management/pacing sound a lot more like a therapy, a lot more scientific, than it is. That was a product of the therapists wanting to be needed, wanting to be the experts, wanting to write energy management...

That would be the Chronic Pain Guideline, the one that recommends acupuncture and did not involve patient organisations. The guideline that doctors had this to say about: It's the Guideline that 150 pain specialists wrote to complain about: (not to mention the (lack of) evidence for...

They (the BPS people) have been busy. They don't seem to have even got all the things they think they agree with right: It's actually ME/CFS. And the guideline did not suggest that GET is an evidence based therapy for CFS/ME or even ME/CFS. The guideline doesn't use the word negotiate...

In Nature Cardiovascular Research, authors are associated with Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Department of Medicine, Division of Infectious Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Department of Medicine...

Yes. I think it is particularly needed if Stanford is still prescribing Abilify to new ME/CFS patients. Like I said, there could be a trial done on those who think that they are getting sustained benefit. How many people do you think there - would there be 20? The ME/CFS clinicians at Stanford...

Yes. I've said it before, even if we can't achieve anything at all, our contribution to human progress can still be greater than that provided by people dedicated to pushing BPS agendas. Even people awarded knighthoods, who are widely feted as successful, may in fact have caused net harm to...

Patient groups might have had a fair excuse before translations facilities on the internet. Now it's just a matter of running papers through some software. The patient group helped these Spanish researchers source participants for the study, a lot of participants. Basic due diligence would...

Interview between Amy Proal and Ilene Ruhoy, 2021