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I'm not sure, but I think the research on reduced blood flow to the brain in ME/CFS is a bit equivocal. The Rowe paper found it, even in people with ME/CFS without overt OI symptoms, but there was another paper that used BOLD imaging that didn't find evidence of reduced blood flow. The idea of...

Have a look at this public thread: Brain fog/ cognitive dysfunction There and elsewhere, it has been said that cognitive dysfunction is perhaps the most debilitating of the symptoms of ME/CFS.

This looks interesting. I look forward to reading the full paper. that's a lowering of the systolic blood pressure at night time. from another paper: normal variation in blood pressure (BP) is characterized by a 10% to 20% reduction in BP from day to night [1]. Individuals with this decline...

Well, attitudes about ME/CFS tend to be a bundle of beliefs, and we have seen some change in some of those beliefs in BACME documents. For example, the understanding of what PEM is is still inadequate, but there is an acceptance that exertion does result in something called PEM. So, I think...

Here's the link to the Supreme Court ruling: https://medicaldialogues.in/pdf_upload/supreme-court-chronic-fatigue-syndrome-192999.pdf I think the article is a bit more positive than the actual Supreme Court ruling. I think the judges ruled that the delay in providing the good care that might...

What would a good aripiprazole trial look like? One way to begin to test it might be to take the group of people diagnosed with ME/CFS who have been taking aripiprazole and believe that it is working for them. Then, have a washout period, and then a blinded crossover trial. If aripiprazole...

https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-7-370 Open access Luis Nacul, Dominic G O’Donovan, Eliana M Lacerda, Djordje Gveric, Kirstin Goldring, Alison Hall, Erinna Bowman & Derek Pheby Abstract Background Our aim, having previously investigated through a qualitative...

It's brief paper. Some interesting bits:

An old thread, but the idea of a post-mortem biobank is often discussed on the forum, and this study was linked in one such discussion. https://jcp.bmj.com/content/63/11/1032 Not open-access Sci-hub link: https://sci-hub.wf/10.1136/jcp.2010.082032 Abstract Background Myalgic...

That patient empowerment has often just been about how clinicians can increase compliance is one of the points the authors make in the abstract though - the authors are saying 'that's not nearly good enough'. I agree that there should not be such a need for self-management as there currently...

This 2013 paper is relevant: Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United States It compared the ALMI (appendicular lean mass index) with quadriceps strength - that might be...

I haven't read the paper, but on the basis of the abstract I agree with @Trish - the paper says nothing about muscle mass being a risk factor for developing Long Covid. And yes, the obvious conclusion from the title is that people with Long Covid have muscle weakness because they are sitting...

From a Solve ME email, an opportunity to join their 'Lived Experience Taskforce: Building on our commitment to centering the crucial voices from our community in the leadership and decision-making at Solve M.E., we are transforming our Community Advisory Council (2019 - 2022) into our new Lived...

The 'artisanal and small-scale' gold mining in Indonesia is often done just by individuals or families using very basic equipment. This isn't corporate mining. These small-scale miners typically live in awful conditions; often this work is done illegally and out of desperation. The workers in...

A discussion of a new Alzheimers treatment has been moved here: An Alzheimer treatment: lecanemab (Biogen)

From an IACFSME email: 1) November 16, 2022 Virtual Journal Club Recording Thank you to Martina Seifert, PhD, for presenting her team's work! Dr. Martina Seifert and Dr. Lavinia Flaskamp discuss their work examining the effect of sera from long COVID patients, some of whom fit ME/CFS...

I agree, it's a major contribution to the forum. Thank you very much to the volunteers who put it together. Please do let others who might find the news summary useful know about it.

We have this discussion thread on neutrophils: Neutrophil issues

This study and others on neutrophils are discussed in this thread: Neutrophil issues