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I take carnitine which seems similar to this drug as it also acts on PPAR and improves utilization of fats for energy production. Carnitine lets me do more and for longer.

A Study to Evaluate ASP0367 in Participants With Reduced Maximum Oxygen Uptake Due to Poor Systemic Oxygen Extraction The purpose of this study is to to evaluate the effect of ASP0367 on improvement of aerobic capacity relative to placebo, as well as evaluate the safety and tolerability of...

I found that comment a bit worrying. The authors might be thinking that they just need to find the right type and dose of exercise.

Who knows. There is no way to show that a person has a repressed emotion or does not have a repressed emotion. By definition if it's repressed then it's not observable. And the method claimed to bring repressed emotions to the surface, ("recovered memory therapy") is now considered a method of...

Excuse me, a radical new understanding? Repressed emotions as cause of disease is what Freud claimed 120 years ago.

CBT imperialism.

Genetic testing can be performed with a device called SNP chip. Not all genetic testing is done with these. Direct-to-consumer genetic testing companies like 23andME often use SNP chips. A problem with SNP chips is that they are unreliable when it comes to rare gene variants. There is the risk...

It's definitely important to know about the problems and limitations with genetic testing. However: The article says that direct-to-consumer genetic testing often uses a method called SNP-chip, which can falsely report the presence of a rare and therefore likely pathogenic variant. This is...

That's an amazing discount and a much more reasonable price for something with uncertain benefit for many patients. I bought it.

Besides labelling glucose a placebo in context of sport, this is also a n=1 story where something very ordinary happens (one cyclist performs better than another) that is then interpreted as supporting conclusions that don't really follow from the observation (the cyclist performed better...

That is quite possibly not a placebo.

I heard about a CBT therapist once who ruined her marriage with compulsive shopping behaviour that she couldn't stop. Isn't that the kind of problem CBT is meant to fix?

I have not read this because it's in Norwegian but still have opinions on questionnaires. Where all questionnaires fail is 1) they appear to be designed for disability that is independent of activity levels, like no longer having legs. 2) they consider each activity in isolation, while in...

Reading up on the things microtubules / tubulin is involved in, is interesting. It's involved in the regulation of cellular energy metabolism and mast cell degranulation and probably many other functions. The link to energy metabolism is the role it plays in the cytoskeleton. It appears that...

There probably exist patients who like being told that there is nothing wrong and that their illness is a figment of their imagination and that they need psychotherapy to stop believing they're ill and/or feel better. But I suspect they like it only because of a combination of specific factors...

A name isn't meant to be a complete description and cannot be one. "syndrome" means "a group of symptoms which consistently occur together". A reader familiar with the meaning of syndrome therefore knows that in PEMS there are other symptoms that typically occur with postexertional malaise.

Lukewarm reception overall, and maybe this: "SEID is killing ME" https://www.meadvocacy.org/seid_is_killing_me Maybe with the next IOM report?

It's obviously PEMS.

I'm sorry, this is my idea :D

How about calling this illness "postexertional malaise syndrome"? It seems such an obviously good name.