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The Oxford diagnostic criteria? It really is all projection in this article, isn't it? ;)

Let's not get overly pessimistic. The authors are feeling threatened and are having difficulty making a coherent response. That suggests the criticism was on target.

If I remember right, Wilshire et al looked at whether cross-over between treatment groups could explain the null results in PACE at followup and concluded it couldn't. Null results remained even if patients who crossed-over were excluded from analysis.

What are they even trying to say here? I read this over and over again trying to understand their reasoning. That certain illnesses don't have an objective diagnostic test doesn't mean that clinical trials of treatments for these illnesses don't suffer from reporting bias affecting the...

Energy-impairment. And it's meant to refer to: low capacity to sustain exertion, slow recovery from exertion.

The National Institute for Health and Care Excellence (NICE) in the UK published a new chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) guideline in October, 2021.The previous NICE 2007 guideline recommended cognitive behavioural therapy (CBT) and graded exercise therapy (GET) for...

Assuming the S1 protein persistence is real, what are the implications? That there is a persistent infection? That the virus has somehow integrated itself into host DNA?

I was unaware of that. Is that written somewhere?

Most major disease will have patient forums for mutual support where pretty much everyone agrees that the disease is "physical". The people who think they're pointing out some unusual and abnormal behaviour don't seem to be bright.

I hope they're heading into a sewer and that the smell will stick to LP for years to come. The national ethics committee won't be pleased to see their "final decision" simply ignored.

If the "semi structural conversation about motivation for change" is new then the study is even worse than the one before that got rejected in terms of bias. If not then nothing has changed substantially. Landmark proving the national ethics committee was right to reject this.

I wish I could swim 20 minutes without pause... Maybe one day, with the right treatment.

Magnesium participates in so many processes that it's hard to know why it's helping. To name some: histamine degradation, energy production, electrolyte transport, glutamate receptors, glutathione synthesis. I read that most of the population in the western world doesn't get enough magnesium...

The author says Sounds like what I've described above (I didn't read the quoted part until afterwards). That eating helps me with this problem to me suggests that there is some metabolic deficit in the brain. This is why I'm so interested in the metabolic side of ME/CFS.

Re. mental exertion causing generalized fatigue. I notice this after spending time on the computer or sitting down to read. I tend to feel increasingly stressed and sick as time goes on. Then when standing up and walking around the house, the fatigue and weakness is so severe that it's visible...

Re. PEM and cognitive exertion. I've been told it's normal to feel generalized fatigue after mental exertion. Maybe in ME/CFS this is more pronounced. And maybe PEM is just what can happen when these pathways are activated: a kind of an emergency brake to stop what is on some level perceived by...

Interesting take on the oxygen extraction problems in ME/CFS. He thinks it's a protective mechanism to manage a redox impairment. The body can't get rid of oxygen metabolites fast enough so it reduces the oxygen consumption to avoid damaging itself. https://paradigmchange.me/wp/cheney/

The studies on NO included were 1. Effects of magnesium supplementation on carotid intima-media thickness and metabolic profiles in diabetic haemodialysis patients 2. Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind...

Effect of magnesium versus placebo on serum nitric oxide.

So this (the nitric oxide) is why epsom salt baths help.