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Agreed. Comparing the same patients before and after inducing PEM would not only ensure that every single participant actually has ME, but it would show if the ME biomarker is really a PEM marker. And I'd control with non-ME deconditioned people, like fatigued cancer patients, before and after...

The URL is messed up FYI.

Maybe it would help elucidate your model to study anecdotes of medication triggering ME/CFS, and seeing if the known drug pathways could potentially mesh with your theory in their effects on the immune or other body systems. For example, with me, marijuana and clozapine (dopamine antagonist)...

I haven't read more than the abstracts, but here are the two studies they reference: Use of symptom-guided physical activity and exercise rehabilitation for COVID-19 and other postviral conditions Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health...

I feel like I'm in wacky world reading this, knowing it's serious scientists in a serious journal. This seems like such an obvious attempt to cloak "PEM isn't real" in some sciencey words to make "you need to exercise" seem like a good conclusion. Like the logic seems to be completely missing...

It seems like he might use a modified Fukuda in his studies which requires PEM. This 2019 study from his lab says "participants with ME/CFS had to meet the following inclusion criteria: (i) age between 18–55 years; (ii) met Fukuda case definition criteria for ME/CFS (Fukuda et al., 1994)...

I added a page to MEpedia for Dextro-naltrexone, basically summarizing what he said in the video.

I haven't dug deeply into this, but might be relevant: Molecular mechanisms underpinning laser printer and photocopier induced symptoms, including chronic fatigue syndrome and respiratory tract hyperresponsiveness: pharmacological treatment with Cinnamon and Hydrogen, 2014 Worth noting that...

I couldn't really figure that out either, but you can press the applause button instead, for one idea per day. Not sure how it differs from an upvote.

https://blogs.bmj.com/bmj/2021/01/25/paul-garner-on-his-recovery-from-long-covid/ Oh wow. I'm almost certain this was a spontaneous recovery unrelated to the happy thoughts. It sounds a lot like some experiences in my own life. There have been times of severe depression/anxiety ebbing and...

Does anyone know if there are researchers, policymakers, or other prominent folks that personally have/had ME/CFS, and are also pushing the psychosomatic theories of CFS?

Is that really what they mean? I haven't read the paper, but if their conclusion is that simple, it's just objectively wrong, at least for me and many other CFS sufferers. I would absolutely love to go on a long hike this weekend. The reason I don't is that for the next week at work I'll have...

Just added my contribution: